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A search for the antisense transcripts that affect higher-order life phenomena in nematodes

Research Project

Project/Area Number 24657121
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Molecular biology
Research InstitutionRitsumeikan University

Principal Investigator

NISHIZAWA Mikio  立命館大学, 生命科学部, 教授 (40192687)

Co-Investigator(Kenkyū-buntansha) OKUYAMA Tetsuya  立命館大学, 理工学研究科, 研究員 (80614966)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsアンチセンス転写物 / RNA / 線虫
Research Abstract

An antisense transcript (asRNA) has a sequence that is complementary to its messenger RNA (mRNA). In this study, we tried to clarify the effects of asRNAs on higher-order life phenomena in a nematode. We confirmed that asRNAs were transcribed from a heat shock factor gene and a gene encoding a protein in the Notch signaling pathway. Then, we constructed a library to express transcripts that were complementary to mRNA. Nematodes were fed with the library to express asRNAs inside of the nematodes, and then phenotypic changes in development or fertility were examined. Indeed, developmental retardation or sterility of the nematodes was observed. Therefore, this method may provide a basis to functionally analyze the asRNAs that are involved in development.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (14 results)

All 2013 2012 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (8 results) Remarks (4 results)

  • [Journal Article] Active hexose correlated compound extends the lifespan and increases the thermotolerance of nematodes2013

    • Author(s)
      Okuyama T, Yoshigai E, Ikeya Y, Nishizawa M
    • Journal Title

      Functional Foods in Health and Disease

      Volume: 3 Pages: 166-182

    • URL

      http://functionalfoodscenter.net/files/69624283.pdf

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Active hexose correlated compound extends the lifespan and increases the thermotolerance of nematodes.2013

    • Author(s)
      Okuyama T, Yoshigai E, Ikeya Y, Nishizawa M
    • Journal Title

      Functional Foods in Health and Disease

      Volume: 3 Pages: 166-182

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 線虫C. elegansの寿命延長と熱耐性に対するAHCCの効果2013

    • Author(s)
      奥山哲矢,吉開会美,池谷幸信,西澤幹雄
    • Organizer
      第21回統合医療機能性食品国際会議(ICNIM2013)
    • Place of Presentation
      ホテルロイトン札幌,札幌(北海道)
    • Year and Date
      2013-07-27
    • Related Report
      2013 Final Research Report
  • [Presentation] Active hexose correlated compound extends lifespan and increases thermotolerance of nematodes2013

    • Author(s)
      Okuyama T, Yoshigai E, Ikeya Y, Nishizawa M
    • Organizer
      The 13th International Conference of Functional Food Center and The First International Symposium of Academic Society for Functional Foods and Bioactive Compounds
    • Place of Presentation
      京都府立医科大学,京都(京都府)
    • Year and Date
      2013-05-12
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of active hexose correlated compound on lifespan and stress resistance of C. elegans2013

    • Author(s)
      Okuyama T, Yoshigai E, Ikeya Y, Nishizawa M
    • Organizer
      American Society for Parenteral and Enteral Nutrition (ASPEN), Clinical Nutrition Week 2013
    • Place of Presentation
      フェニックス,アリゾナ(米国)
    • Year and Date
      2013-02-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of Active Hexose Correlated Compound on Lifespan and Stress Resistance of C. elegans2013

    • Author(s)
      Tetsuya Okuyama, Emi Yoshigai, Yukinobu Ikeya, Mikio Nishizawa
    • Organizer
      American Society for Parenteral and Enteral Nutrition (ASPEN) Clinical Nutrition Week 2013
    • Place of Presentation
      Phoenix, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] 線虫C. elegansの寿命およびラット肝細胞の一酸化窒素産生に与えるAHCCの影響の比較解析2012

    • Author(s)
      奥山哲矢、吉開会美、奥村忠芳、池谷幸信、西澤幹雄
    • Organizer
      第20回統合医療機能性食品国際会議(ICNIM 2012)
    • Place of Presentation
      ホテルロイトン札幌,札幌(北海道)
    • Year and Date
      2012-07-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 線虫C. elegansの寿命およびラット肝細胞の一酸化窒素産生に与える AHCCの影響の比較解析2012

    • Author(s)
      奥山 哲矢、吉開 会美、奥村 忠芳、池谷 幸信、西澤 幹雄
    • Organizer
      第20回統合医療機能性食品国際会議(ICNIM 2012)
    • Place of Presentation
      ホテルロイトン札幌、北海道
    • Related Report
      2012 Research-status Report
  • [Presentation] Active Hexose Correlated Compound Extends Lifespan and Increases Thermotolerance of Nematodes

    • Author(s)
      Okuyama T, Yoshigai E, Ikeya Y, Nishizawa M
    • Organizer
      The 13th International Conference of Functional Food Center and The First International Symposium of Academic Society for Functional Foods and Bioactive Compounds
    • Place of Presentation
      京都府立医科大学, 京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 線虫C. elegansの寿命延長と熱耐性に対するAHCCの効果

    • Author(s)
      奥山 哲矢, 吉開 会美, 池谷 幸信, 西澤 幹雄
    • Organizer
      第21回統合医療機能性食品国際会議 (ICNIM2013)
    • Place of Presentation
      ホテルロイトン札幌, 札幌
    • Related Report
      2013 Annual Research Report
  • [Remarks] 立命館大学 生命科学部生命医科学科医化学研究室ホームページ

    • URL

      http://www.medch.sk.ritsumei.ac.jp/

    • Related Report
      2013 Final Research Report
  • [Remarks] 立命館大学 研究者学術情報データベース

    • URL

      http://research-db.ritsumei.ac.jp/scripts/websearch/index.htm

    • Related Report
      2013 Final Research Report
  • [Remarks] 立命館大学 生命科学部 生命医科学科 医化学研究室(西澤研究室)

    • URL

      http://www.medch.sk.ritsumei.ac.jp/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 立命館大学 研究者学術情報データベース

    • URL

      http://research-db.ritsumei.ac.jp/scripts/websearch/index.htm

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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