Analysis of the possible contribution of perichromosomal field to the chromosomal stability
| Project/Area Number |
24657124
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Molecular biology
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
MASATOSHI Takagi 独立行政法人理化学研究所, 今本細胞核機能研究室, 専任研究員 (60324779)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 分裂期染色体 / 分裂期 / 脱リン酸化酵素 / 細胞分裂期 / 染色体 |
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| Research Abstract |
The outer layer around each mitotic chromosome, which we call PCF for 'perichromosomal field', is a cellular region with unknown functions. Derived from the knowledge obtained from the functional analyses of Ki67 antigen, a major constituent of PCF, we showed the possibility that the PCF might be involved in the 'quality' of the progression of mitosis. The PCF seems to contribute to the efficient progression of mitosis by providing a 'field' for factors such as PP1 gamma; (protein phosphtase 1 gamma;) to localize on mitotic chromosomes in appropriate timing. The PCF might have function also in supporting the structure of mitotic chromosomes from their outside.
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Report
(3 results)
Research Products
(9 results)
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[Journal Article] Ki-67 is a PP1-interacting protein that organizes the mitotic chromosome periphery2014
Author(s)
Booth, D., Takagi, M., Sanchez-Pulido, L., Petfalski, E., Vargiu, G., Samejima, K., Imamoto, N., Ponting, C., Tollervey, D., Earnshaw, W., and Vagnerelli, P.
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Journal Title
DOI
Related Report
Peer Reviewed
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