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Analysis of the possible contribution of perichromosomal field to the chromosomal stability

Research Project

Project/Area Number 24657124
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Molecular biology
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

MASATOSHI Takagi  独立行政法人理化学研究所, 今本細胞核機能研究室, 専任研究員 (60324779)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords分裂期染色体 / 分裂期 / 脱リン酸化酵素 / 細胞分裂期 / 染色体
Research Abstract

The outer layer around each mitotic chromosome, which we call PCF for 'perichromosomal field', is a cellular region with unknown functions. Derived from the knowledge obtained from the functional analyses of Ki67 antigen, a major constituent of PCF, we showed the possibility that the PCF might be involved in the 'quality' of the progression of mitosis. The PCF seems to contribute to the efficient progression of mitosis by providing a 'field' for factors such as PP1 gamma; (protein phosphtase 1 gamma;) to localize on mitotic chromosomes in appropriate timing. The PCF might have function also in supporting the structure of mitotic chromosomes from their outside.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (9 results)

All 2014 2013 2012 Other

All Journal Article (3 results) (of which Peer Reviewed: 1 results) Presentation (4 results) (of which Invited: 1 results) Remarks (2 results)

  • [Journal Article] Ki-67 is a PP1-interacting protein that organizes the mitotic chromosome periphery2014

    • Author(s)
      Booth, D., Takagi, M., Sanchez-Pulido, L., Petfalski, E., Vargiu, G., Samejima, K., Imamoto, N., Ponting, C., Tollervey, D., Earnshaw, W., and Vagnerelli, P.
    • Journal Title

      eLife

      Volume: 27;3

    • DOI

      10.7554/elife.01641

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Control of Nuclear Size by NPC Proteins2014

    • Author(s)
      Takagi, M., and Imamoto, N.
    • Journal Title

      Advances in Experimental Medicine and Biology

      Volume: Vol. 773 Pages: 571-591

    • Related Report
      2013 Final Research Report
  • [Journal Article] Control of Nuclear Size by NPC Proteins2014

    • Author(s)
      Masatoshi Takagi, Naoko Imamoto
    • Journal Title

      Advances in Experimental Medicine and Biology

      Volume: 773 Pages: 571-591

    • DOI

      10.1007/978-1-4899-8032-8_26

    • ISBN
      9781489980311, 9781489980328
    • Related Report
      2013 Annual Research Report
  • [Presentation] Ki67抗原により染色体表層領域へリクルートされるPP1γの役割2013

    • Author(s)
      高木昌俊
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2013-12-05
    • Related Report
      2013 Final Research Report
  • [Presentation] Ki67抗原により染色体表層領域へリクルートされるPP1γの役割2013

    • Author(s)
      高木昌俊、田口温子、西山祐子、今本尚子
    • Organizer
      第63回日本分子生物学会
    • Place of Presentation
      兵庫 神戸ポートアイランド
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Ki67抗原により染色体表層領域へリクルートされるPP1γの役割2012

    • Author(s)
      高木昌俊
    • Organizer
      第30回染色体ワークショップ
    • Place of Presentation
      淡路夢舞台国際会議場
    • Year and Date
      2012-12-20
    • Related Report
      2013 Final Research Report
  • [Presentation] Ki67抗原により染色体表層領域にリクルートされるPP1gの役割2012

    • Author(s)
      高木 昌俊
    • Organizer
      第30回染色体ワークショップ・第11回核ダイナミクス研究会(合同開催)
    • Place of Presentation
      淡路夢舞台国際会議場(兵庫県)
    • Related Report
      2012 Research-status Report
  • [Remarks] 今本細胞核機能研究室ホームページ

    • URL

      http://www.riken.jp/celldynamics/index.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 今本細胞核機能研究室ホームページ

    • URL

      http://www.riken.jp/celldynamics/index.html

    • Related Report
      2013 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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