Elucidation of molecular mechanisms involved in the regulation of the amount of cellular lipids
| Project/Area Number |
24657131
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Cell biology
|
|---|
| Research Institution | Kyushu University (2013-2014)
Kyoto University (2012) |
|---|
Principal Investigator |
IKENOUCHI Junichi 九州大学, 理学(系)研究科(研究院), 准教授 (10500051)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
|---|
| Keywords | 細胞膜脂質 / 脂質量 / リン脂質 / 脂質代謝酵素 / FANTOM4 / 細胞膜 / THP-1細胞 / 生合成 / ダイアシルグリセロール / 生体膜 / THP-1 |
|---|
| Outline of Final Research Achievements |
The amount of cellular lipids need to be accurately controlled. The membranes of mammalian cells contain several thousands of different phospholipid species and their metabolic pathways are very complicated. In this research proposal, I aimed to clarify the rate-determining steps of these metabolic network of phospholipid species in the regulation of the amount of cellular lipids. I revealed that the biosynthesis of diacylglycerol is highly up-regulated when the total amount of cellular lipids is increased.
|
Report
(4 results)
Research Products
(14 results)
-
[Journal Article] EPLIN is a crucial regulator for extrusion of RasV12-transformed cells.2015
Author(s)
Ohoka, A., Kajita, M., Ikenouchi, J., Yako, Y., Kitamoto, S., Kon, S., Ikegawa, M., Shimada, T., Ishikawa, S., and Fujita, Y.
-
Journal Title
Journal of Cell Science
Volume: 128
Pages: 781-789
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
-
-
-
-
-
-
-
-
-
-
-
