| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
Abnormal chromosomal condensation induces binuclear cells with a genetically unstable tetraploidy known to facilitate aneuploid malignancies. We found such binuclear tetraploid cells to be eliminated by a novel type of programmed cell death in Chinese hamster cells. To enable various analyses of the novel cell death, we established human and mouse cell lines where the novel cell death can be induced, and then obtained exhaustive gene expression profiles from human cells before and after induction of the cell death. We found that induction of the cell death was mediated by down-regulated expression of eEF1A1 protein through accumulation of eEF1A1 mRNA into P bodies (Processing bodies), and the binding of CNBP protein to eEF1A1 mRNA was involved in this process.
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