Research Project
Grant-in-Aid for Challenging Exploratory Research
Although counterion movement coupled with Ca2+ release/uptake is probably required for physiologically functioning of intracellular Ca2+ stores, the molecular basis is totally unknown. We recently identified TRIC channels, that likely mediate counter-K+ currents facilitating Ca2+ release. However, TRIC-knockout mice strongly suggest the existence of other channels/transporters mediating counter currents. We attempted to find new candidates for such channels/transporters in this project, and identified Tmem52 and mitsugumin 56 from the muscle sarcoplasmic reticulum.
All 2014 2013 Other
All Journal Article (2 results) Book (1 results) Remarks (2 results)
Circ. Res
Volume: 114 Pages: 706-716
Nat. Commun
Volume: 4 Pages: 1541-1541
http://www.pharm.kyoto-u.ac.jp/biochem/