Relationship between lipid droplets and peroxisomes through the mitochondria-associated ER membrane
| Project/Area Number |
24657141
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Cell biology
|
|---|
| Research Institution | Tokyo University of Pharmacy and Life Science |
|---|
Principal Investigator |
TAGAYA MITSUO 東京薬科大学, 生命科学部, 教授 (30179569)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
谷 佳津子 東京薬科大学, 生命科学部, 教授 (40266896)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 小胞体 / ミトコンドリア / ペルオキシソーム / 脂肪滴 / Syntaxin 17 / Sec16B / サブコンパートメント / Sec16b / syntaxin17 / syntaxin 17 |
|---|
| Research Abstract |
We examined whether the MAM (mitochondria-associated membrane), a subdomain of the endoplasmic reticulum, participates in lipid droplet formation and peroxisome biogenesis. Lipid droplet formation was suppressed by knockdown of MAM-organizing proteins, such as syntaxin17. Rab32 may also contribute to lipid droplet formation. Depletion of Sec16B caused lipid droplet formation and elongation of peroxisomes in a certain cell type, but suppressed lipid droplet formation and shortened peroxisomes in another type of cells. The data suggest that the MAM has an important role in lipid droplet formation, and that there is an intimate relation between lipid droplet formation and peroxisome biogenesis.
|
Report
(3 results)
Research Products
(24 results)
-
-
[Journal Article] Phosphatidic acid-preferring phospholipase A1 regulates mitochondrial dynamics.2014
Author(s)
Baba T, Kashiwagi Y, Arimitsu N, Kogure T, Edo A, Maruyama T, Nakao K, Nakanishi H, Kinoshita M, Frohman MA, Yamamoto A, Tani K.
-
Journal Title
Journal of Biological Chemistry
Volume: 289
Issue: 16
Pages: 11497-11511
DOI
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] Kinesin-5/Eg5 is important for transport of CARTS from the trans-Golgi network to the cell surface.2013
Author(s)
Wakana, Y., Villeneuve, J., van Galen, J., Cruz-Garcia, D., Tagaya, M., and Malhotra, V.
-
Journal Title
J. Cell Biol.
Volume: 202
Issue: 2
Pages: 241-250
DOI
Related Report
Peer Reviewed
-
-
-
-
-
[Journal Article] Contribution of the long form of syntaxin 5 to the organization of the endoplasmic reticulum2012
Author(s)
Miyazaki, K., Wakana, Y., Noda, C., Arasaki, K., Furuno, A., and Tagaya, M.
-
Journal Title
J. Cell Sci
Volume: 125
Issue: 23
Pages: 5658-5666
DOI
Related Report
Peer Reviewed
-
[Journal Article] Calsyntenin-1 shelters APP from proteolytic processing during anterograde axonal transport2012
Author(s)
Steuble, M., Diep, T. M., Schätzle, P., Ludwig, A., Tagaya, M., Kunz, B., and Sonderegger, P.
-
Journal Title
Biol,Open
Volume: 1
Issue: 8
Pages: 761-774
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
[Book] Chapter 5 The Structures and Functions of Intracellular Phospholipase A_1 Family Proteins, in"Phospholipases in Health and Disease", Eds. Tappia, P. S, and Dhalla, N. S.2014
Author(s)
Tani, K., Baba, T., and Inoue, K.
Publisher
Springer Science+Business Media New York
Related Report
-
-
