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The machanism of nuclear formation for calcium carbonate biomineralization: the analysis using a medaka mutant

Research Project

Project/Area Number 24657146
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Developmental biology
Research InstitutionThe University of Tokyo

Principal Investigator

TAKEDA Hiroyuki  東京大学, 理学(系)研究科(研究院), 教授 (80179647)

Co-Investigator(Renkei-kenkyūsha) OONISHI Yasuo  東京大学, 大学院農学生命科学研究科, 教授 (90292789)
KONDO Mariko  東京大学, 大学院理学系研究科, 准教授 (70372414)
KIYOMOTO Masato  お茶の水女子大学, 人間文化創成科学研究科, 准教授 (70251692)
Research Collaborator HAMANAKA Gen  お茶の水女子大学, 人間文化創成科学研究科, 講師
Project Period (FY) 2012-04-01 – 2013-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Keywords器官形成 / バイオミネラル / 耳石 / ポリケチド合成酵素 / メダカ / ポリケタイド合成酵素 / 結晶核 / メダカポリケタイド合成酵素
Research Abstract

Calcium carbonate biominerals participate in diverse physiological functions and have impacts on global carbon and calcium cycles (e.g. coral reef). However, little is known about how mineralization is initiated in organisms. The medaka mutant ha lacks a trigger for otolith (calcium carbonate ear stone) mineralization, and the causative gene was found to encode polyketide synthase (OlPKS), a multifunctional enzyme mainly found in bacteria, fungi and plant including calcified algae. Subsequent experiments demonstrate that the products of OlPKS act as nucleation facilitators in otolith mineralization. The generality of this novel PKS function is supported by the essential role of echiderm PKS in calcareous skeleton formation together with the presence of PKSs in a much wider range of animals from coral to vertebrates. The present study first links PKS to biomineralization and provides a genetic cue for biogeochemistry of carbon and calcium cycles.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (7 results)

All 2013 Other

All Presentation (5 results) Remarks (2 results)

  • [Presentation] New insight into biomineralization from the medaka mutant,ha2013

    • Author(s)
      武田洋幸
    • Organizer
      UTOKYO FORUM2013
    • Place of Presentation
      サンチャゴ(チリ)
    • Year and Date
      2013-11-07
    • Related Report
      2013 Final Research Report
  • [Presentation] メダカ耳石変異体からバイオミネラル形成の謎に迫る2013

    • Author(s)
      武田洋幸
    • Organizer
      東北大学大学院生命科学研究科附属浅虫海洋生物学教育研究センター秋の浅虫研究会
    • Place of Presentation
      浅虫海洋生物学教育研究センター(青森)
    • Year and Date
      2013-10-19
    • Related Report
      2013 Final Research Report
  • [Presentation] メダカ耳石変異体からバイオミネラル形成の謎に迫る2013

    • Author(s)
      武田洋幸
    • Organizer
      京都産業大学総合生命科学部バイオフォーラム2013
    • Place of Presentation
      京都産業大学(京都)
    • Year and Date
      2013-09-06
    • Related Report
      2013 Final Research Report
  • [Presentation] メダカ耳石変異体からバイオミネラル形成の謎に迫る2013

    • Author(s)
      武田洋幸
    • Organizer
      秋の浅虫研究会
    • Place of Presentation
      東北大学大学院生命科学研究科附属浅虫海洋生物学教育研究センター(青森)
    • Related Report
      2013 Annual Research Report
  • [Presentation] New insight into biomineralization from the medaka mutant, ha.2013

    • Author(s)
      武田洋幸
    • Organizer
      UTOKYO FORUM 2013
    • Place of Presentation
      Santiago, Chile
    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.bs.s.u-tokyo.ac.jp

    • Related Report
      2013 Final Research Report
  • [Remarks] 動物発生学研究室

    • URL

      http://www.biol.s.u-tokyo.ac.jp/users/hassei/

    • Related Report
      2013 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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