Developmental origin of vertebrate exoskeleton
| Project/Area Number |
24657148
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Developmental biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Shimada Atsuko 東京大学, 理学(系)研究科(研究院), 助教 (20376552)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | exoskeleton / 外骨格 / 鱗 / 鰭条 / 骨格の起源 / 軟骨魚 / 細胞系譜 |
|---|
| Outline of Final Research Achievements |
The vertebrate mineralized skeleton is known to have first emerged as an exoskeleton that extensively covered the fossil jawless fish. The evolutionary origin of this exoskeleton has long been attributed to the emergence of the neural crest, but experimental evaluation for this is still poor. Here we tried to develop long-term labeling methods to Dogfish (Scyliorhinus canicula) in order to determine the embryonic origin of ancestral scales. It was found that labeling of somite cells could be possible by injection of DNA with 30 gage needles that are inserted through a thinned eggshell. Next we tried to find the progenitor cells of fins and scales within zebrafish somites and suggested that a small cell population near the notochord could be a candidate progenitor for bone forming cells of the fins and scales.
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Report
(5 results)
Research Products
(8 results)
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[Journal Article] Unexpected link between polyketide synthase and calcium carbonate biomineralization2015
Author(s)
Motoki Hojo, Ai Omi, Gen Hamanaka, Kazutoshi Shindo, Atsuko Shimada, Mariko Kondo, Takanori Narita, Masato Kiyomoto, Yohei Katsuyama, Yasuo Ohnishi, Naoki Irie and Hiroyuki Takeda
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Journal Title
Zoological Letters
Volume: 1
Issue: 1
Pages: 1-16
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A neural mechanism underlying mating preferences for familiar individuals in medaka fish.2014
Author(s)
Okuyama T, Yokoi S, Abe H, Isoe Y, Suehiro Y, Imada H, Tanaka M, Kawasaki T, Yuba S, Taniguchi Y, Kamei Y, Okubo K, Shimada A, Naruse K, Takeda H, Oka Y, Kubo T, Takeuchi H
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Journal Title
Science (New York, N.Y.)
Volume: 343
Issue: 6166
Pages: 91-94
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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