Identification of muscle support cells generated during muscledifferentiation
Project/Area Number |
24657154
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Developmental biology
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Research Institution | Kyoto University |
Principal Investigator |
SEHARA Atsuko 京都大学, 再生医科学研究所, 教授 (60209038)
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Project Period (FY) |
2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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Keywords | 筋形成 / 筋衛星細胞 / 幹細胞 / 細胞外基質 / 細胞間相互作用 / 骨格筋 / 筋芽細胞 / MyoD / myogenin / 蛍光タンパク質 |
Research Abstract |
Mechanisms of myogenesis induced by myogenin have been elusive. Wehave succeeded to isolate myogenin-negative cells from differentiating myoblast C2C12cells, and have found that those ells express sets of genes different from myogeninpositive cells by microarray. One of these genes is expressed in regions adjacent tomuscle, and knockdown of this gene significantly affected myogenesis and enhancedapoptosis in zebrafish, supporting an idea that this gene and cells expressing this geneare involved in the maintenance or survival of muscle cells. Whether these cells aregenerated from muscle satellite cells was examined.
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Report
(2 results)
Research Products
(25 results)
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[Journal Article] Activity-dependent proteolytic cleavage of neuroligin-12012
Author(s)
Suzuki K, Hayashi Y, Nakahara S, Kumazaki H, Prox J, Horiuchi K, Zeng M, Tanimura S, Nishiyama Y, Osawa S, Sehara-Fujisawa A, Saftig P, Yokoshima S, Fukuyama T, Matsuki N, Koyama R, Tomita T, Iwatsubo T.
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Journal Title
Neuron
Volume: 76(2)
Issue: 2
Pages: 410-422
DOI
Related Report
Peer Reviewed
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[Presentation] ENGRAFTMENT OF MOUSE FETAL MYOGENIC PROGENITORS INTO DYSTROPHIC MUSCLES
Author(s)
Sakai, Hiroshi, Sato, Takahiko, Sakurai, Hidetoshi, Hanaoka,Kazunori, Montarras, Didier, Buckingham, Margaret, Sehara-Fujisawa, Atsuko
Organizer
International Society for Stem Cell Research 10th Annual Meeting
Place of Presentation
神奈川県
Related Report
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[Presentation] ROLES OF ADAM8 FOR SKELETAL MUSCLE REGENERATION
Author(s)
Nishimura, Daigo, Sakai, Hiroshi, Sato, Takahiko, Iida, Atsuo, Sato, Fuminori, Bartsch, Jörg W., Sehara-Fujisawa, Atsuko
Organizer
International Society for Stem Cell Research 10th Annual Meeting
Place of Presentation
神奈川県
Related Report
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