Research Project
Grant-in-Aid for Challenging Exploratory Research
An experimental model system for molecular genetics in newts is necessary to clarify the mechanisms of regeneration from the perspective of gene functions. We have introduced Iberian ribbed newt (Pleurodeles waltl) as the suitable model newts. In the results of our researches, we have been able to shorten the periods for sexual maturation, and are developing 2 inbred and various transgenic lines of P. waltl newts. We also demonstrated that Cre-loxP recombination system efficiently worked in the newts. In addition, we achieved targeted gene knockout in the newt using TALENs. These results show that conditional knockout newts would be available by combination of Cre-loxP recombination and TALENs. Our system would be very powerful for studying the molecular mechanisms of not only regeneration but also various researches. In relation to the result of this research, we published total 12 research and review papers, also our group had 29 conference presentations.
All 2014 2013 2012 Other
All Journal Article (16 results) (of which Peer Reviewed: 10 results, Open Access: 1 results) Presentation (58 results) (of which Invited: 15 results) Book (1 results) Remarks (6 results)
J. Biol. Chem
Volume: (in press) Issue: 26 Pages: 18033-18044
10.1074/jbc.m113.541953
Dev. Growth. Differ
Volume: (in press) Issue: 5 Pages: 402-409
10.1111/dgd.12134
40020109544
Biochem. Biophys. Res. Commun.
Volume: 443 Issue: 3 Pages: 1105-1109
10.1016/j.bbrc.2013.12.109
Development, Growth and Differentiation
Volume: 56 Issue: 1 Pages: 115-121
10.1111/dgd.12103
細胞工学
Volume: 33 Pages: 203-207
実験医学
Volume: 32 Pages: 29-35
Dev. Growth. Differ.
Volume: 印刷中
Volume: 別册 Pages: 180-188
Mech Dev.
Volume: 130 Issue: 11-12 Pages: 519-31
10.1016/j.mod.2013.07.002
Development, Growth & Differentiation
Volume: 55 Issue: 2 Pages: 229-36
10.1111/dgd.12019
Volume: 31 Pages: 205-211
Volume: 54 Issue: 8 Pages: 731-8
10.1111/j.1440-169x.2012.01373.x
Molecular Cell
Volume: 45 Issue: 1 Pages: 123-131
10.1016/j.molcel.2011.10.018
J. Neurosci
Volume: 12 Issue: 37 Pages: 12876-12884
10.1523/jneurosci.2250-12.2012
http://toridaimedseitai.web.fc2.com/index.html
http://www.med.tottori-u.ac.jp/biosign/5982.html