| Project/Area Number |
24657158
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
NOMURA TADASHI 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (10323007)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 大脳皮質 / 中間増殖細胞 / Tbr2 / outer radial glial / 羊膜類 / 進化 / 外套 / outer radial glia |
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| Research Abstract |
To explore the evolutionary origin of mammalian intermediate progenitors, we analyzed progenitor characteristics in non-mammalian pallium. Mammalian intermediate progenitors are Tbr2-positive and undergo mitosis at the basal side of the cortex (basal progenitors: BPs). On the contrary, BPs and Tbr2-positive cells in the developing avian pallium are distinct cell population; the former resemble outer radial glial cells in primates, whereas the latter are post-mitotic neurons. Our results suggest that BPs have independently evolved in mammalian and avian lineages, which provided encephalization in these two amniote groups.
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