Evolution of cortical intermediate progenitors and Tbr2 gene functions
| Project/Area Number |
24657158
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Developmental biology
|
|---|
| Research Institution | Kyoto Prefectural University of Medicine |
|---|
Principal Investigator |
NOMURA TADASHI 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (10323007)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 大脳皮質 / 中間増殖細胞 / Tbr2 / outer radial glial / 羊膜類 / 進化 / 外套 / outer radial glia |
|---|
| Research Abstract |
To explore the evolutionary origin of mammalian intermediate progenitors, we analyzed progenitor characteristics in non-mammalian pallium. Mammalian intermediate progenitors are Tbr2-positive and undergo mitosis at the basal side of the cortex (basal progenitors: BPs). On the contrary, BPs and Tbr2-positive cells in the developing avian pallium are distinct cell population; the former resemble outer radial glial cells in primates, whereas the latter are post-mitotic neurons. Our results suggest that BPs have independently evolved in mammalian and avian lineages, which provided encephalization in these two amniote groups.
|
Report
(3 results)
Research Products
(34 results)
-
-
-
[Journal Article] Development of the prethalamus is crucial for thalamocortical projection formation and is regulated by Olig22014
Author(s)
K. Ono, A. Clavairoly, T. Nomura, H. Gotoh, Uno, O. Armant, H. Takebayashi, Q. Zhang, K. Shimamura, S. Itohara, CM. Parras, K. Ikenaka.
-
Journal Title
Development
Volume: 141
Pages: 2075-84
Related Report
Peer Reviewed
-
-
[Journal Article] Development of the prethalamus is crucial for thalamocortical projection formation and is regulated by Olig22014
Author(s)
Ono K, Clavairoly A, Nomura T, Gotoh H, Uno A, Armant O, Takebayashi H, Zhang Q, Shimamura K, Itohara S, Parras CM, Ikenaka K.
-
Journal Title
Development
Volume: in press
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
