Analysis of spatiotemporal patterning of WNT proteins that regulate asymmetric patterning
| Project/Area Number |
24657159
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | National Institute of Genetics |
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Principal Investigator |
IHARA Shinji 国立遺伝学研究所, 構造遺伝学研究センター, 助教 (70373272)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | WNT / 非対称分裂 / 可視化 / Wnt |
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| Research Abstract |
It is assumed that a WNT proteins show hydrophilic character based on amino acid sequence. However, these proteins are highly hydrophobic due to adding the lipid and stick tightly to cell membrane and extracellular matrix. To understand spaciotemporal patterning of WNT proteins and extracellular matrix, we use asymmetric division which are regulated by WNT as a model system in C. elegans. We have obtained some results about visualization of WNT molecule and extracellular matrix in vivo.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] The novel secreted factor MIG-18 acts with MIG-17/ADAMTS to control cell migration in Caenorhabditis elegans.2014
Author(s)
Kim H-S, Kitano Y, Mori M, Takano T, Harbaugh TE, Mizutani K, Yanagimoto H, Miwa S, Ihara S, Kubota Y, Shibata Y, Ikenishi K, Garriga G and Nishiwaki K.
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Journal Title
Genetics
Volume: 196(2)
Issue: 2
Pages: 471-479
DOI
URL
Related Report
Peer Reviewed / Open Access
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