| Project/Area Number |
24657165
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Evolutionary biology
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | Thermoplasma / T. acidophilum / 食作用 / 真核生物 / 古細菌 / 細胞共生説 / 電子顕微鏡 / 共焦点顕微鏡 / ナノドット / 超薄切片 / 連続切片 / 3D画像 |
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| Research Abstract |
Eukaryotic cell has been originated by the endosymbiosis of eubacteria forming organelle in an archaebacterial host cell. Though the eukaryotic cells have characteristics unique to eukaryotes, the origin of these unique characteristics has not been elucidated. Phylogenetic analysis revealed that the origin of the phagocytosis is related to the homolog of cytoskeleton found in archaebacteria. However, phagocytosis has never been found in prokaryotic cells. We have recently observed the characteristics suggesting the possible phagocytosis in cellular structure of an archaeon Thermoplasma acidophilum. In this work we have constructed 3D structures of the cells from continuous micrographs of ultrathin sections and analyzed the structure with confocal laser microscope, suggesting the phagocytosis in the archaeon.
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