Construction of RNA life-like System Entirely from Prebiotic Materials Formed on the Primitive Earth

• Project/Area Number: 24657166
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Evolutionary biology
• Research Institution: Hiroshima Shudo University
• Principal Investigator: KUNIO Kawamura 広島修道大学, 人間環境学部, 教授 (50204772)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 生命起源 / 人工生命 / 化学進化 / 複製の起源 / RNAワールド / 核酸化学 / 実験進化学 / RNAの自然選択 / 分析化学

Research Abstract

To construct a replication system of RNA molecules using entirely prebiotic materials on the primitive earth, the RNA formations were attempted. The results suggest the difficulty of RNA replication using entirely prebiotic molecules on the primitive earth.

Research Products

• [Journal Article] 文明の生命システム論からみる地球環境保全─教育と研究活動の役割─ (2014)
  • Author(s): 川村邦男
  • Journal Title: 人間環境学研究 Volume: 12 Pages: 65-83
  • NAID: 120005419359
• [Journal Article] Oligopeptide production from alanine monomer by pulsed corona discharge plasma in ambient and supercritical argon (2013)
  • Author(s): Koichi Nagafuchi, Atsushi Nagira, Hidenori Akiyama, Mitsuru Sasaki, Kunio Kawamura
  • Journal Title: Chemical Engineering and Science Volume: 1 (3) Pages: 41-45
  • Peer Reviewed
• [Journal Article] Difficulty of the self-replication of prebiotic RNA molecules (2013)
  • Author(s): Kunio Kawamura, Yoshimi Maruoka, Kazuyasu Hamahiga, Noriko Konagaya
  • Journal Title: Goldschmidt Abstract,Mineralogical Magazine,Florence, Italy Volume: 1440
  • Peer Reviewed
• [Journal Article] Oligopeptide production from alanine monomer by pulsed corona discharge plasma in ambient and supercritical argon (2013)
  • Author(s): Koichi Nagafuchi, Atsushi Nagira, Hidenori Akiyama, Mitsuru Sasaki*, Kunio Kawamura
  • Journal Title: Chemical Engineering and Science Volume: 1 Issue: 3 Pages: 41-45
  • DOI: 10.12691/ces-1-3-2
  • Peer Reviewed
• [Journal Article] 文明の生命システム論からみる地球環境保全 ─教育と研究活動の役割─ (2013)
  • Author(s): 川村邦男
  • Journal Title: 人間環境学研究 Volume: 12 Pages: 65-83
  • NAID: 120005419359
• [Journal Article] Experimental studies of partial melting at the contact between limestone and politic gneiss. Goldschmidt 2013 Conference abstract, Firenze (2013)
  • Author(s): Kato, M., Hiroi, Y., and Arima, M.
  • Journal Title: Mineralogical Magazine Volume: 77 (5) Issue: 5 Pages: 1436-1436
  • DOI: 10.1180/minmag.2013.077.5.11
  • Peer Reviewed
• [Journal Article] Recent progress for the peptide synthesis using hydrothermal -microflow reactor systems (2012)
  • Author(s): Kunio Kawamura
  • Journal Title: Peptide Science Pages: 132-124
  • NAID: 10031161571
  • Peer Reviewed
• [Journal Article] Behavior of a hammerhead ribozyme in aqueous solution at medium to high temperatures (2012)
  • Author(s): Nizar El-Murr, Marie-Christine Maurel, Martina Rihova, Jacques Vergne, Guy Hervé, Mikio Kato, Kunio Kawamura
  • Journal Title: Naturwissenschaften Volume: 99 Pages: 731-738
  • Peer Reviewed
• [Journal Article] High-throughput Ru(III) analysis using the hydrothermal flow reactor-mediated FIA by the extreme acceleration of Ru(III) complexation with 1,10-phenanthroline (2012)
  • Author(s): Kunio Kawamura, Takayuki Nakai, Keisuke Ikoma, Hideaki Hisamoto
  • Journal Title: Talanta Volume: 99 Pages: 415-419
  • Peer Reviewed
• [Journal Article] Drawbacks of the ancient RNA-based life-like system under primitive earth conditions (2012)
  • Author(s): Kunio Kawamura
  • Journal Title: Biochimie Volume: 94 (7) Pages: 1441-1450
  • Peer Reviewed
• [Journal Article] Bulk- and surface-modified combinable PDMS capillary sensor array as easy-to-use sensing device with enhanced sensitivity to elevated concentrations of multiple serum sample components (2012)
  • Author(s): Yuji Fujii, Terence G. Henares, Kunio Kawamura, Tatsuro Endo, Hideaki Hisamoto
  • Journal Title: Lab Chip Volume: 12 (8) Pages: 1522-1526
  • Peer Reviewed
• [Journal Article] Recent progress for the peptide synthesis using hydrothermal-microflow reactor systems (2012)
  • Author(s): Kunio Kawamura
  • Journal Title: Peptide Science Volume: - Pages: 123-124
  • NAID: 10031161571
  • Peer Reviewed
• [Presentation] 生命の定義を再考する (2014)
  • Author(s): 川村邦男
  • Organizer: 生命の起原および進化学会第39回学術講演会
  • Place of Presentation: 広島
• [Presentation] 生命の定義を再考する (2014)
  • Author(s): 川村邦男
  • Organizer: 生命の起原および進化学会第３９回学術講演会
  • Place of Presentation: 広島市
• [Presentation] 水中ナノパルス放電におけるアラニルアラニンの反応経路及び反応機構 (2013)
  • Author(s): 坂井夕華・柳楽篤史・佐々木満・後藤元信・川村邦男
  • Organizer: 化学工学会第45回秋季大会
  • Place of Presentation: 岡山市
• [Presentation] 文明の生命システム論からみる環境問題に対する教育と科学技術の役割 (2013)
  • Author(s): 川村邦男
  • Organizer: 日本環境学会東広島大会(第39回研究発表会)
  • Place of Presentation: 東広島
• [Presentation] Environment harmless technology on the basis of old-fashioned chemistry : usage of classical analytical reactions for highly sensitive and selective, high-through put, small sample size metal analyses (2013)
  • Author(s): Kunio Kawamura
  • Organizer: The 2nd EnvironmentAsia International Conference on"Human Vulnerability and Global Environmental Change"
  • Place of Presentation: Pataya, Thailand
• [Presentation] The role of education and invention for global environmental protection on the basis of the biosystem view of civilization (2013)
  • Author(s): Kunio Kawamura
  • Organizer: The 2nd EnvironmentAsia International Conference on"Human Vulnerability and Global Environmental Change"
  • Place of Presentation: Pataya, Thailand
• [Presentation] Effect of pulsed discharge plasma irradiation on the elongation of alanine and alanylalanine under ambient aqueous and hydrothermal conditions (2013)
  • Author(s): Mitsuru Sasaki, Atsushi Nagira, Koichi Nagafuchi, Armando T.Motonobu Goto, Kunio Kawamura
  • Organizer: Quitain, Wahyudiono,ISPlasma2013
  • Place of Presentation: Nagoya, Japan
• [Presentation] 10～200℃における水溶液中でのハンマーヘッドリボザイムの自己切断挙動 (2013)
  • Author(s): Nizal El-Murr, Marie-Christine Maurel, Martina Říhová, Jacques Vergne, Guy Hervé,加藤幹男,川村邦男
  • Organizer: 第38回生命の起源および進化学会学術講演会
  • Place of Presentation: 福岡
• [Presentation] Difficulty of the self-replication of prebiotic RNA molecules (2013)
  • Author(s): Kunio Kawamura, Yoshimi Maruoka, Kazuyasu Hamahiga, Noriko Konagaya
  • Organizer: Goldschmidt 2013
  • Place of Presentation: Florence
• [Presentation] 熱水マイクロフローリアクター技術を用いるペプチド生成反応に関する最近の進展 (2012)
  • Author(s): 川村邦男
  • Organizer: ペプチド討論会
  • Place of Presentation: 鹿児島(要旨集P002)
• [Presentation] 鉱物‐熱水フローリアクターを用いる原始ペプチド生成モデルの解析 (2012)
  • Author(s): 川村邦男・竹家均・櫛部崇夫・古泉ゆか(広島修道大人間環境・大阪府大院工)
  • Organizer: 2012年度日本地球化学会年会
  • Place of Presentation: 福岡
• [Presentation] Elucidation of factors affecting elongation of alanine and alanyl alanine in discharged plasma induced hydrothermal treatment (2012)
  • Author(s): Atsushi Nagira, Koichi Nagafuchi, Mitsuru Sasaki, Kunio Kawamura (Japan)
  • Organizer: BIOELECTRICS 2012, 9th International Bioelectrics Symposium
  • Place of Presentation: Kumamoto, KKR Hotel Kumamoto, Japan
• [Presentation] Peptide synthesis from amino acid by pulsed discharge plasma in pressurized fluids (2012)
  • Author(s): Koichi Nagafuchi, Atushi Nagira, Hidenori Akiyama, Mitsuru Sasaki, Kunio Kawamura (Japan)
  • Organizer: BIOELECTRICS 2012, 9th International Bioelectrics Symposium
  • Place of Presentation: Kumamoto, KKR Hotel Kumamoto, Japan
• [Presentation] 熱水マイクロフローリアクター技術を用いるペプチド生成反応に関する最近の進展 (2012)
  • Author(s): 川村邦男
  • Organizer: ペプチド討論会
  • Place of Presentation: 鹿児島
• [Book] Oligomerization of nucleic acids and peptides under the primitive earth conditions in "Oligomerization of Chemical and Biological Compounds" (2014)
  • Author(s): Kunio Kawamura
  • Total Pages: 36
  • Publisher: InTech
• [Book] Reality of the emergence of life-like systems from simple prebiotic polymers on primitive earth"in"GENESIS - IN THE BEGINNING : Precursors of Life, Chemical Models and Early biological Evolution"Eds. by Joseph Seckbach and Richard Gordon (2012)
  • Author(s): Kunio Kawamura
  • Publisher: Springer
• [Book] “Reality of the emergence of life-like systems from simple prebiotic polymers on primitive earth” in “GENESIS - IN THE BEGINNING: Precursors of Life, Chemical Models and Early biological Evolution” Eds. by Joseph Seckbach and Richard Gordon (2012)
  • Author(s): Kunio Kawamura
  • Publisher: Springer
• [Remarks]
  • URL: http://ns1.shudo-u.ac.jp/~kawamura/index.html