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A study on mushroom genome information for understanding the human genome evolution

Research Project

Project/Area Number 24657171
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Physical anthropology
Research InstitutionJichi Medical University

Principal Investigator

NAKAYAMA Kazuhiro  自治医科大学, 医学部, 講師 (90433581)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsゲノム / キノコ類 / 次世代シーケンサー / 多型 / 人類進化 / ヒト / ゲノム多様性 / 高速シーケンサー / 人類学 / 進化
Outline of Final Research Achievements

Analyses of genome information of organisms that coexist with humans would provide valuable clues to understanding the human evolution. Mushrooms have been utilized as foods and medicines for a long time and thus are considered to be good candidates for this purpose. In the preset study, to clarify whether genome information of mushrooms can be used to draw insights into the evolution of humans, the whole genome sequence of a mycorrhizal fungi species, Lactirus volumes, was determined by using massively parallel sequencing methods and the whole genome polymorphism pattern was evaluated. Additionally, optimization of the DNA extraction method for wild-captured fruit bodies was attempted. The preset study showed that L.volumes has a highly polymorphic genome and was suitable for subjects of evolutionary population genetics.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (3 results)

All 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] ゲノム多様性情報から集団を科学する2014

    • Author(s)
      中山一大
    • Journal Title

      日本生理人類学会誌

      Volume: 19 Pages: 263-267

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] 「生物基礎」と「生物」で理解するヒトの遺伝と進化2014

    • Author(s)
      中山一大
    • Organizer
      第68回日本人類学会大会
    • Place of Presentation
      静岡県浜松市
    • Year and Date
      2014-11-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] ゲノム多様性情報からヒト集団を科学する。2014

    • Author(s)
      中山一大
    • Organizer
      日本生理人類学会第70回大会
    • Place of Presentation
      福岡県福岡市
    • Year and Date
      2014-06-21
    • Related Report
      2014 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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