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Characterization of basic structure and function of a new ribozyme linking groups of subviral RNA pathogen

Research Project

Project/Area Number 24658036
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Plant pathology
Research InstitutionHirosaki University

Principal Investigator

SANO Teruo  弘前大学, 農学生命科学部, 教授 (30142699)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsサブウイルスRNA病原体 / ウイロイド / サテライトRNA / リボザイム / ヘアピン型リボザイム / ハンマーヘッド型リボザイム / 環状1本鎖RNA / サブウイルスRNA病原体 / サテライトRNA
Research Abstract

Subviral RNA pathogen is a group of small RNA consisting of viroid which replicates autonomously depending on host transcription machinery and virus satellite RNA which replicates depending on host virus. Among them, viroid and viroid-like small circular satellite RNA are thought to be a same origin because they share similar molecular size, structure, and functions such as ribozyme activity.
Here in this research, we have analyzed a new viroid-like small circular RNA isolated from mulberry (Morus alba) cultivated in China on the molecular structures, genetic diversity and new ribozyme activity found in the minus strand, and detected a couple of mutations which could change the potential of ribozyme activity. Taking the lacking of ability to replicate autonomously and the structural similarity of new ribozyme to hairpin-ribozyme in considerations, Mulberry small circular RNA can be placed in small circular viral satellite RNA group.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (4 results)

All 2014 2013 Other

All Journal Article (1 results) Presentation (2 results) (of which Invited: 1 results) Remarks (1 results)

  • [Journal Article] Threats to Japanese agriculture from newly emerged plant viruses and viroids2014

    • Author(s)
      Tsuda S, Sano T
    • Journal Title

      J Gen Pl Pathol

      Volume: 80 Pages: 2-14

    • NAID

      130004779387

    • Related Report
      2013 Final Research Report
  • [Presentation] Molecular ecology of viroids and viroid diseases of crop plants2013

    • Author(s)
      Teruo Sano
    • Organizer
      Special lecture in Botanical Society, University of Mysore (Department of Studies Botany)
    • Place of Presentation
      Mysore, India
    • Year and Date
      2013-12-02
    • Related Report
      2013 Final Research Report
  • [Presentation] Current status of viroid disease epidemics in the world2013

    • Author(s)
      Teruo Sano
    • Organizer
      2013 Korean Society of Plant Pathology. International Conference
    • Place of Presentation
      Sunchon National University, Sunchon Korea
    • Year and Date
      2013-10-18
    • Related Report
      2013 Final Research Report
    • Invited
  • [Remarks]

    • URL

      http://nature.cc.hirosaki-u.ac.jp/lab/3/plapath/

    • Related Report
      2013 Final Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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