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Systems construction of production of human metabolism derived from volatile components using Spodoptera litura.

Research Project

Project/Area Number 24658055
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Applied entomology
Research InstitutionKinki University

Principal Investigator

MIYAZAWA mitsuo  近畿大学, 理工学部, 教授 (40140305)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords応用昆虫 / ハスモンヨトウ / 体内動態 / テルペノイド / ヒト肝 / テルぺノイド
Research Abstract

We investigated human metabolism of terpenes. Besides, we succeeded in the identification of the P450 species which participated in those metabolism. In addition, we examine a metabolism study as a substrate using Spodoptera litura larvae because human metabolism and the metabolism products of S. litura closely resemble. Therefore, we succeeded systems construction of production of human metabolism derived from volatile components using S. litura. The results suggested that human metabolism products are supplied conveniently to the global society.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (39 results)

All 2014 2013 2012

All Journal Article (24 results) (of which Peer Reviewed: 24 results) Presentation (14 results) Book (1 results)

  • [Journal Article] Volatile components with aroma properties of Indiann herval medicine Pavonia odorata-used in Ayurveda2014

    • Author(s)
      Yusei Kashima, Satoshi Nakaya, Mitsuo Miyazawa
    • Journal Title

      J. Oleo Sci.

      Volume: 63 Pages: 149-158

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of agitake (Pleurotus eryngii var. ferulae) volatile componets with characteri- stic odors extracted by hydrodis- tillaton and solvent-assisted flavor evaporation2014

    • Author(s)
      Atsushi Usami, Toshirou Ono, Yusei Kashima, Hiroshi Nakahashi, Shinsuke Marumoto, Sota Nosaka, Shogo Watanabe, Mitsuo Miyazawa
    • Journal Title

      J. Oleo Sci.

      Volume: 63 Pages: 83-92

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chemical composition and major odor-active compounds of essential oil from Pinellia Tuber (dried rhizome of Pinellia ternata) as Crude Drug2014

    • Author(s)
      Megumi Iwasa, Toshiki Iwasaki, Toshir- ou Ono, Mitsuo Miyazawa
    • Journal Title

      J. Oleo Sci.

      Volume: 63 Pages: 127-135

    • NAID

      130004436103

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chemical Composition and Aroma Evaluation of Essential Oils from Evolvulus alsinoides L.2014

    • Author(s)
      Kashima, Yusei; Miyazawa, Mitsuo
    • Journal Title

      Chemistry & Biodiversity

      Volume: 11 Pages: 396-407

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Volatile components with aroma properties of Indiann herval medicine Pavonia odorata-used in Ayurveda.2014

    • Author(s)
      Yusei Kashima, Satoshi Nakaya, Mitsuo Miyazawa
    • Journal Title

      J. Oleo Sci.

      Volume: 63 Pages: 149-158

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of agitake (Pleurotus eryngii var. ferulae) volatile componets with characteristic odors extracted by hydrodistillaton and solvent-assisted flavor evaporation.2014

    • Author(s)
      Atsushi Usami, Toshirou Ono, Yusei Kashima, Hiroshi Nakahashi, Shinsuke Marumoto, Sota Nosaka, Shogo Watanabe, Mitsuo Miyazawa
    • Journal Title

      J. Oleo Sci.

      Volume: 63 Pages: 83-92

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemical composition and major odor-active compounds of essential oil from Pinellia Tuber (dried rhizome of Pinellia ternata) as Crude Drug.2014

    • Author(s)
      Megumi Iwasa, Toshiki Iwasaki, Toshirou Ono, Mitsuo Miyazawa
    • Journal Title

      J. Oleo Sci.

      Volume: 63 Pages: 127-135

    • NAID

      130004436103

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis, antioxidant capacity, and structure-activity relationships of tri-O-methylnorbergenin analogues on tyrosinase inhibition2013

    • Author(s)
      Yusei Kashima, Mitsuo Miyazawa
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 23 Pages: 6580-6584

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of volatiles from Ampel- opsis brevipedunculata var. hetero- hylla Using GC-Olfactometry, GC-MS and GC-pulsed flame photometric detector2013

    • Author(s)
      Atsuhiko Nakamura, Mitsuo Miyazawa
    • Journal Title

      J. Oleo Sci.

      Volume: 62 Pages: 645-655

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Volatile compounds with characteristic aroma of boiled sweet potato (Ipomoea batatas L. cv Ayamurasaki, I. batatas L. cv Beniazuma and I. batatas L. cv Simon 1)2013

    • Author(s)
      Atsuhiko Nakamura, Toshirou Ono, Nobuo Yagi, Mitsuo Miyazawa
    • Journal Title

      J. Essent. Oil Res.

      Volume: 25 Pages: 497-505

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biotransformation of serotonin derivatives by the larvae of common cutworm (Spodoptera litura)2013

    • Author(s)
      Toshiyuki Takahashi, Mitsuo Miyazawa
    • Journal Title

      Nat. Prod. Res.

      Volume: 27 Pages: 592-596

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characteristic chemical components of the essential oil from white kwao krua (Pueraria mirifica)2013

    • Author(s)
      Nobuo Yagi, Hiroshi Nakahashi, Tomohiro Kobayashi, Mitsuo Miyazawa
    • Journal Title

      J. Oleo Sci.

      Volume: 62 Pages: 175-179

    • NAID

      130004436028

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characteristic odor components of essential oil from Scutellaria laeteviolacea2013

    • Author(s)
      Mitsuo Miyazawa, Machi Nomura, Shinsuke Marumoto, Kiyoshige Mori
    • Journal Title

      J. Oleo Sci.

      Volume: 62 Pages: 51-56

    • NAID

      130004800065

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis, antioxidant capacity, and structure-activity relationships of tri-O-methylnorbergenin analogues on tyrosinase inhibition.2013

    • Author(s)
      Yusei Kashima, Mitsuo Miyazawa
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 23 Pages: 6580-6584

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of volatiles from Ampelopsis brevipedunculata var. heterohylla Using GC-Olfactometry, GC-MS and GC-pulsed flame photometric detector2013

    • Author(s)
      Atsuhiko Nakamura, Mitsuo Miyazawa
    • Journal Title

      J. Oleo Sci.

      Volume: 62 Pages: 645-655

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characteristic odor components of essential oil from Scutellaria laeteviolacea.2013

    • Author(s)
      Mitsuo Miyazawa, Machi Nomura, Shinsuke Marumoto, Kiyoshige Mori
    • Journal Title

      J. Oleo Sci.

      Volume: 62 Pages: 51-56

    • NAID

      130004800065

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characteristic chemical components of the essential oil from white kwao krua (<i>Pueraria mirifica</i>)2013

    • Author(s)
      Yagi, Nobuo; Nakahashi, Hiroshi; Kobayashi, Tomohiro; Miyazawa, Mitsuo
    • Journal Title

      Journal of Oleo Science

      Volume: 62 Issue: 3 Pages: 175-179

    • DOI

      10.5650/jos.62.175

    • NAID

      130004436028

    • ISSN
      1345-8957, 1347-3352
    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characteristic Odor Components of Essential Oil from <i>Scutellaria laeteviolacea</i>2013

    • Author(s)
      Miyazawa, Mitsuo; Nomura, Machi; Maumoto, Shinsuke; Mori, Kiyoshige
    • Journal Title

      Journal of Oleo Science

      Volume: 62 Issue: 1 Pages: 51-56

    • DOI

      10.5650/jos.62.51

    • NAID

      130004800065

    • ISSN
      1345-8957, 1347-3352
    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synthesis and biological evaluation of bergenin analogues as mushroom tyrosinase inhibitors2012

    • Author(s)
      Yusei Kashima, Mitsuo Miyazawa
    • Journal Title

      Arch. Pharm. Res.

      Volume: 35 Pages: 1533-1541

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characteristic odor components of essential oil from Caesalpinia decapetala2012

    • Author(s)
      Mitsuo Miyazawa, Tsukasa Nagata, Hiroshi Nakahashi, Toshiyuki Takahashi
    • Journal Title

      J. Essent. Oil Res.

      Volume: 24 Pages: 441-446

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparative analysis of volatile compounds from corms of Crocus sativus and C. vernus2012

    • Author(s)
      Atsunori Msuda, Kiyoshige Mori, Mitsuo Miyazawa
    • Journal Title

      Chem. Nat. Comp.

      Volume: 48 Pages: 319-321

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and biological evaluation of bergenin analogues as mushroom tyrosinase inhibitors2012

    • Author(s)
      Kashima, Yusei; Miyazawa, Mitsuo
    • Journal Title

      Archives of Pharmacal Research

      Volume: 35 Issue: 9 Pages: 1533-1541

    • DOI

      10.1007/s12272-012-0903-3

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characteristic odor components of essential oil from Caesalpinia decapetala2012

    • Author(s)
      Miyazawa, Mitsuo; Nagata, Tsukasa; Nakahashi, Hiroshi; Takahashi, Toshiyuki
    • Journal Title

      Journal of Essential Oil Research

      Volume: 24 Issue: 5 Pages: 441-446

    • DOI

      10.1080/10412905.2012.703475

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparative analysis of volatile compounds from corms of Crocus sativus and C. vernus2012

    • Author(s)
      Masuda, Atsunori; Mori, Kiyoshige; Miyazawa, Mitsuo
    • Journal Title

      Chemistry of Natural Compounds

      Volume: 48 Issue: 2 Pages: 319-321

    • DOI

      10.1007/s10600-012-0236-y

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Structure-activity Relationsips for Bergenin Analogues as β-Secretase (BACE1) Inhibition2014

    • Author(s)
      宮澤 三雄
    • Organizer
      13th International Geneva/Springfield Symposium on Advances in Alzheimer Therapy
    • Place of Presentation
      Geneva, Switzerland
    • Related Report
      2013 Annual Research Report
  • [Presentation] 生体触媒としてハスモンヨトウ (Spodoptera litura) を用いた (-)-myrtenalの生物変換2014

    • Author(s)
      本岡 良太、宇佐見 享嗣、宮澤 三雄
    • Organizer
      日本農芸化学会 2014年度 (平成26年度) 大会 [東京]
    • Place of Presentation
      明治大学 生田キャンパス (神奈川)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヒト肝ミクロソーム中のシトクロムP450による4-thujanolの変換2013

    • Author(s)
      清水良祐、伊東星都、宮澤三雄
    • Organizer
      香料・テルペンおよび精油化学に関する討論会
    • Place of Presentation
      埼玉
    • Related Report
      2013 Final Research Report
  • [Presentation] 生体触媒としてハスモンヨトウを用いたcamphorquinoneの生物変換2013

    • Author(s)
      宇佐見享嗣、野阪創太、宮澤三雄
    • Organizer
      香料・テルペンおよび精油化学に関する討論会
    • Place of Presentation
      埼玉
    • Related Report
      2013 Final Research Report
  • [Presentation] 生体触媒としてハスモンヨトウ(Spodoptera litura)を用いたLime oxide Tの生物変換2013

    • Author(s)
      本岡良太、宇佐見享嗣、宮澤三雄
    • Organizer
      香料・テルペンおよび精油化学に関する討論会
    • Place of Presentation
      埼玉
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒト肝ミクロソーム中のシトクロムP450による4-thujanolの変換2013

    • Author(s)
      清水 良祐、伊藤 星都、宮澤 三雄
    • Organizer
      第57回 香料・テルペンおよび精油化学に関する討論会
    • Place of Presentation
      埼玉大学 (埼玉)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 生体触媒としてハスモンヨトウを用いたcamphorquinoneの生物変換2013

    • Author(s)
      宇佐見 享嗣、野阪 創太、宮澤 三雄
    • Organizer
      第57回 香料・テルペンおよび精油化学に関する討論会
    • Place of Presentation
      埼玉大学 (埼玉)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 生体触媒としてハスモンヨトウ(Spodoptera litura)を用いたLime oxide Tの生物変換2013

    • Author(s)
      本岡 良太、宇佐見 享嗣、宮澤 三雄
    • Organizer
      第57回 香料・テルペンおよび精油化学に関する討論会
    • Place of Presentation
      埼玉大学 (埼玉)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヒト肝ミクロソーム中のシトクロムP450によるgeraniolの変換2012

    • Author(s)
      伊東星都、宮澤三雄
    • Organizer
      香料・テルペンおよび精油化学に関する討論会
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Final Research Report
  • [Presentation] 精油構成分子のヒト体内動態と機能性発現2012

    • Author(s)
      宮澤三雄
    • Organizer
      香料・テルペンおよび精油化学に関する討論会
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Final Research Report
  • [Presentation] 生体触媒としてハスモンヨトウ(Spodoptera litura)を用いた4-thujanolの生物変換2012

    • Author(s)
      神足悟史、宮澤三雄
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Final Research Report
  • [Presentation] 生体触媒としてハスモンヨトウを用いた(+)-および(-)-campheneの生物変換2012

    • Author(s)
      宇佐見享嗣、神足悟史、堀部功、宮澤三雄
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒト肝ミクロソーム中のシトクロムP450による geraniol の変換2012

    • Author(s)
      伊藤星都・宮澤三雄
    • Organizer
      香料・テルペンおよび精油化学に関する討論会
    • Place of Presentation
      鹿児島大学郡元キャンパス
    • Related Report
      2012 Research-status Report
  • [Presentation] 精油構成分子のヒト体内動態と機能性発現2012

    • Author(s)
      宮澤三雄
    • Organizer
      香料・テルペンおよび精油化学に関する討論会
    • Place of Presentation
      鹿児島大学郡元キャンパス
    • Related Report
      2012 Research-status Report
  • [Book] アロマのある空間2012

    • Author(s)
      宮澤三雄
    • Total Pages
      167
    • Publisher
      日経BP
    • Related Report
      2013 Final Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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