Novel strategy to awake gene cluster using small molecules that activate LAL family transcriptional regulator
Project/Area Number |
24658088
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Single-year Grants |
Research Field |
Applied microbiology
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Research Institution | Institute of Physical and Chemical Research |
Principal Investigator |
TAKAHASHI Shunji 独立行政法人理化学研究所, 環境資源科学研究センター, ユニットリーダー (30311608)
|
Project Period (FY) |
2012-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 休眠遺伝子覚醒 / バイオメディエーター / LALファミリー / 小分子化合物 / 転写制御因子 |
Research Abstract |
Genome sequencing of Streptomyces spp. revealed many unknown secondary metabolite gene clusters that might be potential sources for a medicinal drug and an agricultural chemical. The objective of the study is an activation of secondary metabolite gene clusters using small molecules. LAL family transcriptional regulators are widely found in Streptomyces spp. Among them, we focused on RevU which exists in reveromycin biosynthetic gene cluster. We searched a small molecule which activates reveromycin production, and optimized its chemical structure. This study gave great insights for the mechanism of the activation of secondary metabolite gene cluster.
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Report
(3 results)
Research Products
(62 results)
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[Journal Article] RK-1355A and B, novel quinomycin derivatives isolated from a microbial metabolites fraction library based on NPPlot screening.2014
Author(s)
Lim CL, Nogawa T, Uramoto M, Okano A, Hongo Y, Nakamura T, Koshino H, Takahashi S, Ibrahim D, Osada H.
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Journal Title
J Antibiot (Tokyo)
Volume: 67
Issue: 4
Pages: 323-329
DOI
Related Report
Peer Reviewed
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