| Project/Area Number |
24658112
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | Hokkaido University |
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Principal Investigator |
HARA HIROSHI 北海道大学, (連合)農学研究科(研究院), 教授 (70198894)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | プラスマローゲン / トランス脂肪酸 / 動脈硬化 / 血管内皮細胞 / LC-MS/MS / 動脈硬化症 |
|---|
| Research Abstract |
Plasmalogen is a subclass of glycerophospholipids with radical-sensitive chemical structure, and suggested as an endogenous anti-atherogenic factor. Fatty acids with trans form are well-known atherogenic dietary components, however, the mechanisms are not full clarified. We found that a trans-form FA was abundantly incorporated into plasmalogen molecules by feeding of trans fatty acids for 4 weeks in rats. Application of a LDL fraction of trans fatty acid-fed rats to a cultured blood vessel endothelial cell, HUVEC, enhanced gene and protein expression of VCAM1, a adhesion factor for monocyte to blood vessel endothelium, and MCP1, a chemoattractant for monocyte in the cells. These results suggest that trans fatty acids incorporated into plasmalogen is an inducer of the atherogenic changes in the blood vessels.
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