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Elucidation of mechanisms to avoid chronic inflammation via enteroendocrine system: relationships between immune cells and adipocytes

Research Project

Project/Area Number 24658114
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Food science
Research InstitutionHokkaido University

Principal Investigator

ISHIZUKA Satoshi  北海道大学, (連合)農学研究科(研究院), 准教授 (00271627)

Co-Investigator(Renkei-kenkyūsha) HIRA Tohru  北海道大学, 大学院農学研究院, 講師 (10396301)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordschronic inflammation / interleukin-6 / メタボリック症候群 / 脂肪組織 / 慢性炎症 / 消化管内分泌系 / glucagon-like peptide / 腸管リンパ / 腸間膜リンパ節
Outline of Final Research Achievements

Diet-induced obesity induces chronic inflammation. At postplandial period, various external antigens other than dietary lipids get into lymph ducts and evoke immune responses. In this study, we evaluated factors in lymph ducts by using lymph-cannulated rats especially at a postplandial period. At several hours after administration of dietary lipids, there was a significant increase of interleukin-6(IL-6) and glucagon-like peptide-1 in the lymph. Gene expression analysis in food-deprived or fed rats indicated that an accumulation of IL-6 producing cells in the intestinal mucosa accompanied by lipid absorption.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (2 results)

All Other

All Presentation (2 results)

  • [Presentation] 腸管関連リンパ液採取法の検討と脂質吸収に伴う構成成分の経時的変化

    • Author(s)
      3. 山岸 晋也、野勢 琢馬、菊地 慧大、清水 英寿、西向 めぐみ、原 博、石塚 敏
    • Organizer
      第43回 日本栄養・食糧学会北海道支部会
    • Place of Presentation
      札幌 北海道大学
    • Related Report
      2013 Research-status Report
  • [Presentation] Evaluation of isolation and culture procedure for sodium periodate-induced peritoneal elicited cells as a model system of functional analysis in primary macrophages.

    • Author(s)
      Joe GH, Andoh M, Shimizu H, Hara H, Ishizuka S.
    • Organizer
      日本農芸化学会北海道支部夏期シンポジウム
    • Place of Presentation
      旭川 旭川国際会議場
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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