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Development of assay system for evaluating the effect of functional foods on the prevention of brain aging

Research Project

Project/Area Number 24658117
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Food science
Research InstitutionThe University of Tokyo

Principal Investigator

HISATSUNE Tatsuhiro  東京大学, 新領域創成科学研究科, 准教授 (10238298)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords脳老化予防 / 食品成分 / 食品機能成分 / 高機能食品成分 / 脳老化の予防 / アルツハイマー病モデルマウス
Outline of Final Research Achievements

Brain aging is a normal biological process, but it may also be a risk factor for various dementias, such as Alzheimer’s disease. It has been suggested that healthy lifestyle choices, such as regular physical exercise and social interactions, may decelerate the brain aging process. Dietary improvements may also protect the aging brain; however, few studies have assessed this possibility. In this study, we have developed the two assay systems based on mouse study and human study, for evaluating the effect of dietary supplementation on the prevention of brain aging.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (5 results)

All 2013 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] β-Alanyl-L-Histidine Rescues Cognitive Deficits Caused by Feeding a High Fat Diet in a Transgenic Mouse Model of Alzheimer’s Disease2013

    • Author(s)
      Herculano B, Tamura M, Ohba A, Shimatani M, Kutsuna N, Hisatsune T
    • Journal Title

      Journal of Alzheimer’s Disease

      Volume: 33 Issue: 4 Pages: 983-997

    • DOI

      10.3233/jad-2012-121324

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Contribution of the P2Y1 receptor to hippocampal neuroinflammation and cognitive decline in a rodent model of focal cerebral stroke2013

    • Author(s)
      Chin Y, Kishi M, Sekino M, Nakajo F, Abe Y, Ohsaki H, Kato F, Koizumi S, Gac het C, Hisatsune T
    • Journal Title

      Journal of Neuroinflammation

      Volume: 26 Issue: 1 Pages: 10-95

    • DOI

      10.1186/1742-2094-10-95

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 抗酸化食品成分のアルツハイマー病の予防に関する動物モデル研究2013

    • Author(s)
      芝原恵、田村南、Bruno Heruculano、久恒辰博
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      東北大学川内北キャンパス
    • Related Report
      2012 Research-status Report
  • [Presentation] 高機能食品素材の脳老化に対する予防・改善効果の評価に適した人体用MRI脳画像計測法の確立2013

    • Author(s)
      樋口陽太、大庭綾香、阿部欽史、陳揚、左達秀敏、中村純二、時光一郎、久恒辰博
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      東北大学川内北キャンパス
    • Related Report
      2012 Research-status Report
  • [Remarks] 東京大学大学院新領域創成科学研究科/先端生命科学専攻/細胞応答化学分野/久恒研究室

    • URL

      http://park.itc.u-tokyo.ac.jp/hisatsune-lab/

    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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