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Exploration of the role of microRNAs in nutrition response

Research Project

Project/Area Number 24658118
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Food science
Research InstitutionThe University of Tokyo

Principal Investigator

KATO Hisanori  東京大学, 総括プロジェクト機構, 特任教授 (40211164)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
KeywordsマイクロRNA / アミノ酸 / タンパク質栄養 / 遺伝子発現 / ロイシン / マイクロアレイ / アミノ酸欠乏 / HepG2 / miRNA / グルコース / DNAマイクロアレイ
Research Abstract

Micro-RNAs (miRNA) are small RNAs that do not encode proteins and regulate the expression of a variety of genes by interacting with their mRNAs. Aiming at finding miRNAs that respond to nutritional conditions, we performed DNA microarray analysis. An interesting finding was the up-regulation of miR-149* in response to the deficiency of leucine, an essential amino acid. In addition, we manipulated the amount of miR-203, a miRNA which respond to low protein diet, in cultured cells. As miR-203 target, we identified Naa50, a factor involved in cancer and cell growth.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (6 results)

All 2013 Other

All Presentation (6 results) (of which Invited: 1 results)

  • [Presentation] Integration of multiple omics for the study of food functionality2013

    • Author(s)
      Hisanori Kato
    • Organizer
      2013 International symposium for the Cheonan Food Expo
    • Place of Presentation
      天安市(韓国)
    • Year and Date
      2013-09-06
    • Related Report
      2013 Final Research Report
  • [Presentation] 低タンパク質食摂取の影響を受けるmiRNAであるmiR-203の標的遺伝子の探索2013

    • Author(s)
      高橋薫、高橋祥子、斉藤憲司、加藤久典
    • Organizer
      第67回日本栄養・食糧学会大会
    • Place of Presentation
      名古屋大学(愛知県)
    • Year and Date
      2013-05-25
    • Related Report
      2013 Final Research Report
  • [Presentation] A study on the effects of low protein diet on hepatic miRNA and its target genes by microarray analysis2013

    • Author(s)
      K Takahashi, K Saito, S Takahashi1, H Kato
    • Organizer
      The 20th International Congress of Nutrition
    • Place of Presentation
      グラナダ(スペイン)
    • Related Report
      2013 Final Research Report
  • [Presentation] Integration of Multiple Omics for the study of Food Functionality2013

    • Author(s)
      Hisanori Kato
    • Organizer
      2013 International symposium for the Cheonan Food Expo
    • Place of Presentation
      天安市、韓国
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] A study on the effects of low protein diet on hepatic miRNA and its target genes by microarray analysis2013

    • Author(s)
      K Takahashi, K Saito, S Takahashi1, H Kato
    • Organizer
      The 20th International Congress of Nutrition
    • Place of Presentation
      グラナダ、スペイン
    • Related Report
      2012 Research-status Report
  • [Presentation] 低タンパク質食摂取の影響を受けるmiRNAであるmiR-203の標的遺伝子の探索

    • Author(s)
      高橋薫、高橋祥子、斉藤憲司、加藤久典
    • Organizer
      第67回日本栄養・食糧学会大会
    • Place of Presentation
      名古屋大学(愛知県)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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