| Project/Area Number |
24658122
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Nagoya University |
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Principal Investigator |
UCHIDA Koji 名古屋大学, 生命農学研究科, 教授 (40203533)
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| Project Period (FY) |
2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Keywords | イソチオシアネート / イベリン / 抗炎症性 / 自然炎症 / グルタチオン / グルタチオン化 / 抱合体 / Toll様受容体 |
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| Research Abstract |
We have investigated the Toll-like receptor (TLR) signaling inhibitory potential of food-derived small molecules. Based on an extensive screening of Brassica vegetable extracts for the TLR-inhibitory activity, we found cabbage as the richest source and identified 3-(methylsulfinyl)propyl isothiocyanate (iberin), an analogue of sulforaphane isolated from broccoli, as one of the major TLR inhibitor in cabbage. We also studied glutathiolation and protein reactivity of iberin.
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