| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
We found existence of food allergens as immune complexes with specific IgAs in mother's milk and have proposed a hypothesis that mother's milk is a natural drinkable vaccine for food allergy prevention. In this research, we proved that both natural IgA immune complex prepared from human saliva and pseudo immune complex which chemically coupled ovalbumin with IgA showed vaccine function as a direct factor for tolerance induction in mice. In addition, we clarified reinforcement effect by the probiotics on this tolerance induction.
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