| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Sugar-lipid hybrid structures are expected to be effective for fruit body induction. Then, compounds library including glyceroglycolipid analogs and glucosylceramides with various designed structures were constructed based on chemical synthetic approach. From the fruiting assay against Pleurotus ostreatus by paper disc method, the structure-activity relationship depending on the numbers of glucose units, carbon numbers of acyl chains, and differences in aglycon structures were suggested. Finally, the chemical substances which stimulate hyphal aggregation and primordia formation at fairly low concentration (10μg/disk for a glyceroglycolipid analog, 1μg/disk for a glucosylceramid) were successfully found in the assessment of the minimum effective dose.
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