| Project/Area Number |
24658226
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Zootechnical science/Grassland science
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| Research Institution | Mie University |
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Principal Investigator |
KONDO Makoto 三重大学, 生物資源学研究科, 助教 (50432175)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | デオキシニバレノール / アンモニア / 細胞毒性 / アンモニア処理 / 毒性 |
|---|
| Research Abstract |
Research was conducted to determine the effect of ammonia exposure to trichothecene mycotoxin, deoxynivalenol (DON). DON concentration decreased by ammonia exposure in a dose dependent manner. DON was transformed both reversibly and irrevesibly by a short period (24 h) of ammoniation. In contrast, after 3 weeks ammoniation, DON was not detected completely. Cytotoxicity to human leukemia cell line HL60 by DON-NH3 reacted solution was present after 24 h reaction, but not detected any toxicity after 3 week reaction.
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