| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Many primordial follicles in livestock ovaries are discarded without being effectively used in the slaughterhouse. The aim of my study is to save the oocytes with excellent genetic traits in the ovaries, which are discarded without being effectively used. Less than 1% of primordial follicles are ovulated, and the remainders are eliminated via atresia. The precise mechanisms involved in the regulation of follicule selection remain unknown. Recent my studies suggest that apoptosis in follicular granulosa cells plays a crucial role in the oocyte selection. Cell death ligand and receptor systems are the key mechanisms regulating granulosa cell apoptosis. I revealed the roles of intracellular apoptosis inhibitory factors (cFLIP, XIAP, DcR3 etc.), which are useful to assess the damaged and/or healthy oocytes and save the oocyte including the follicle. Then, I have developed a method to save the oocyte with the help of these inhibitors.
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