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Rescue of potential oocytes in livestock ovaries by artificial control of apoptosis inhibitor

Research Project

Project/Area Number 24658231
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Applied animal science
Research InstitutionThe University of Tokyo

Principal Investigator

MANABE Noboru  東京大学, 農学生命科学研究科, 教授 (80243070)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsアポトーシス / アポトーシス阻害因子 / 卵巣内潜在的卵母細胞 / 家畜卵巣 / 卵胞 / 顆粒層細胞 / 細胞死リガンド・受容体系 / カスパーゼ系 / 卵巣 / 卵巣内潜在的卵子 / カスパーゼ / 卵子救済 / 卵胞選抜 / 哺乳類 / 発現制御
Outline of Final Research Achievements

Many primordial follicles in livestock ovaries are discarded without being effectively used in the slaughterhouse. The aim of my study is to save the oocytes with excellent genetic traits in the ovaries, which are discarded without being effectively used. Less than 1% of primordial follicles are ovulated, and the remainders are eliminated via atresia. The precise mechanisms involved in the regulation of follicule selection remain unknown. Recent my studies suggest that apoptosis in follicular granulosa cells plays a crucial role in the oocyte selection. Cell death ligand and receptor systems are the key mechanisms regulating granulosa cell apoptosis. I revealed the roles of intracellular apoptosis inhibitory factors (cFLIP, XIAP, DcR3 etc.), which are useful to assess the damaged and/or healthy oocytes and save the oocyte including the follicle. Then, I have developed a method to save the oocyte with the help of these inhibitors.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (74 results)

All 2015 2014 2013 2012 Other

All Journal Article (27 results) (of which Peer Reviewed: 23 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (36 results) (of which Invited: 9 results) Book (8 results) Remarks (3 results)

  • [Journal Article] 好気性超高温発酵堆肥の抗大腸菌群効果の検討2015

    • Author(s)
      9.小堤悠平,長峰孝文,高橋友継,畠中哲哉,道宗直昭, 眞鍋昇
    • Journal Title

      畜産環境学会誌

      Volume: 14 Pages: 1-8

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expressions of tumor necrosis factor-α, its receptor I, II and receptor-associated factor 2 in the porcine corpus luteum during the estrous cycle and early pregnancy2014

    • Author(s)
      3.Chie Suzuki, Koji Yoshioka, Manabu Yamada, Michiko Noguchi, Noboru Manabe
    • Journal Title

      Veterinary Research Communications

      Volume: 38 Pages: 1-10

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cutting edge of bovine reproductive technology: Production of prion gene KO cow to prevent spontaneous BSE2014

    • Author(s)
      1.Noboru Manabe, Ichiro Onoyama, Yutaka Sendai, Yoshito Aoyag
    • Journal Title

      The Thai Journal of Veterinary Medicine

      Volume: 44 Pages: 105-110

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of radionuclides due to the accident of the Fukushima Daiichi Nuclear Power Plant on the recycling agriculture including livestock2014

    • Author(s)
      3.Noboru Manabe, Tomotusgu Takahashi, Junyou Li, Keitarou Tanoi, Tomoko Nakanishi
    • Journal Title

      New Food Industry

      Volume: 56 Pages: 45-50

    • NAID

      40020211400

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Increased collagen III in culled chicken meat after feeding dietary wood charcoal and vinegar contributes to palatability and tenderness2014

    • Author(s)
      4.Kohsyo Yamauchi, Noboru Manabe, Yoshiki Matsumoto, Shin-Ichi Takenoyama, Koh-En Yamauchi
    • Journal Title

      Animal Science Journal

      Volume: 85 Pages: 468-480

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Method for determination of histamine in food by LC-MS/MS2014

    • Author(s)
      5.Yoshito Ohtsubo, Hiroyuki Kurooka, Hisae Tada, Noboru Manabe
    • Journal Title

      Journal of Food Hygiene and Safety Science

      Volume: 55 Pages: 103-109

    • NAID

      130004504402

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hallmarks of hepatitis C virus in equine hepaciviru2014

    • Author(s)
      6.Tomohisa Tanaka, Hirotake Kasai, Atsuya Yamashita, Kaori Okuyama-Dobashi, Jun Yasumoto, Shinya Maekawa, Nobuyuki Enomoto, Toru Okamoto, Yoshiharu Matsuura, Masami Morimatsu, Noboru Manabe, Kazuhiko Ochiai, Kazuto Yamashita, Kohji Moriishi
    • Journal Title

      Journal of Virology

      Volume: 88 Pages: 13352-13366

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 原発事故に関わる家畜と畜産物の安全性について2014

    • Author(s)
      7.眞鍋昇,高橋友継,李俊佑,田中哲弥,田野井慶太朗,中西友子
    • Journal Title

      畜産の研究

      Volume: 68 Pages: 1085-1090

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 畜産物の安全」を重視した畜産廃棄物処理の将来2014

    • Author(s)
      眞鍋昇,高橋友継,李俊佑
    • Journal Title

      畜産の研究

      Volume: 68 Pages: 447-451

    • Related Report
      2014 Annual Research Report
  • [Journal Article] produced and characterized after serial centrifugations2013

    • Author(s)
      Nguyen Viet Linh, Kazuhiro Kikuchi, Michiko Nakai, Junko Noguchi, Hiroyuki Kaneko, Thanh Quang Dang-Nguyen, Tamas Somfai, Bui Xuan Nguyen, Takashi Nagai, Noboru Manabe
    • Journal Title

      The Journal of Reproduction and Development

      Volume: 59 Pages: 549-556

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Saving genetic resources of native pigs in occidental and oriental countries: Practical examples of the characterization and utilization of native pigs in Hungary and Laos2013

    • Author(s)
      Jozsef Ratky, Istvan Egerszegi, Peter Toth, Soukanh Keonuchan, Takashi Nagai, Kazuhiro Kikuchi, Noburu Manabe, Klaus-Peter Brussow
    • Journal Title

      The Journal of Reproduction and Development

      Volume: 59 Pages: 437-441

    • NAID

      130003381849

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tenc1 deficient mice develop glomerular disease in a strain-specific manner2013

    • Author(s)
      Kozue Uchio-Yamada, Kyoko Sawada, Kotaro Tamura, Sumie Katayama, Youko Monobe, Yoshie Yamamoto, Atsuo Ogura, Noboru Manabe
    • Journal Title

      Nephron Experimental Nephrology

      Volume: 123 Pages: 22-33

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Gene expression analysis detected low expression level of C1s gene in ICR-derived glomerulonephritis (ICGN) mice2013

    • Author(s)
      Kotaro Tamura, Kozue Uchio-Yamada, Noboru Manabe, Takahisa Noto, Rika Hirota, Masahiro Matsumoto, Yoich Miyamae
    • Journal Title

      Nephron Experimental Nephrology

      Volume: 123 Pages: 34-45

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of treadmill exercise and hydrogen-rich water intake on serum oxidative and antioxidative metabolites in serum of thoroughbred horses2013

    • Author(s)
      Hirokazu Tsubone, Masakazu Hanafusa, Maiko Endo, Noboru Manabe, Atsushi Hiraga, Hajime Ohmura, Hiroko Aida
    • Journal Title

      Journal of Equine Science

      Volume: 24 Pages: 1-8

    • NAID

      10031167539

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Breed differences in dopamine receptor D4 gene (DRD4) in horses2013

    • Author(s)
      Yusuke Hori, Takatoshi Ozaki, Shin-ichi Ito, Yoshimitsu Yamada, Teruaki Tozaki, Heui-Soo Kim, Noboru Manabe, Miho Inoue-Murayama, Kazuo Fujita
    • Journal Title

      Journal of Equine Science

      Volume: 24 Pages: 31-36

    • NAID

      130004431257

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Follicular growth and atresia in mammalian ovaries: Regulation by survival and death of granulosa cells.2012

    • Author(s)
      Fuko Matsuda, Naoko Inoue, Noboru Manabe, Satoshi Ohkura
    • Journal Title

      Journal of Reproduction and Development

      Volume: 58 Pages: 44-50

    • NAID

      10030407021

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of RNA interference of Bid and Bax mRNAs on apoptosis in granulosa cell-derived KGN cells.2012

    • Author(s)
      Takafumi Sai, Fuko Matsuda, Yasufumi Goto, Akihisa Maeda, Miki Sugimoto, Hongmei Gao, Abul Khair Mohammad Ahan Kabir, Junyou Li. Noboru Manabe.
    • Journal Title

      Journal of Reproduction and Development

      Volume: 58 Pages: 112-116

    • NAID

      10030407425

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Follicular turnover and hormonal association in postpartum goats during early and late lactation.2012

    • Author(s)
      Mohamed M. M. Kandiel, Gen Watanabe, Mahmoud E. A. Abou-El-Roos, Alaa E. Abdel-Ghaffar, Gamal A. Sosa, Abd El-Salam I. El-Azab, Kentaro Nagaoka, Junyou Li, Noboru Manabe, Kazuyoshi Taya
    • Journal Title

      Journal of Reproduction and Development

      Volume: 58 Pages: 61-68

    • NAID

      10030407153

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Epigenetic effect of amino acids sppliment on the growth of infant cattle.2012

    • Author(s)
      Noboru Manabe, Junyou Li
    • Journal Title

      Livestock Technology

      Volume: 56 Pages: 16019-16019

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Transition to the milk of radioactive materials in feed for dairy cattle and future pollution control.2012

    • Author(s)
      Noboru Manabe, Junyou Li, Tomotsugu Takahashi, Maiko Endo, Yuriko Emoto, Keitaro Tanoi, Kennta Sakurai, Tomoko Nakanishi
    • Journal Title

      Dairy Japan

      Volume: 12 Pages: 25-27

    • Related Report
      2012 Research-status Report
  • [Journal Article] Regulation mechanism of ovarian follicle selection by anti-apoptotic factor, cellular FLICE-inhibitory protein (cFLIP) in mammals.2012

    • Author(s)
      Fuko Matsuda, Noboru Manabe
    • Journal Title

      Comparative Endocrinology

      Volume: 38 Pages: 27-32

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of linoleic acid albumin in a dilution solution and long-term equilibration for freezing of bovine spermatozoa with poor freezability.2012

    • Author(s)
      Toshikiyo Takahashi, Ryu Itoh, Hiroshi Nishinomiya, Noboru Manabe.
    • Journal Title

      Reproduction in Domestic Animals

      Volume: 47 Pages: 92-97

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Supplementation of culture medium with L-carnitine improves development and cryotolerance of bovine embryos produced in vitro.2012

    • Author(s)
      Toshikiyo Takahashi, Yasushi Inaba, Tamas Somfai, Masahiro Kaneda, Masaya Geshi, Takashi Nagai, Noboru Manabe.
    • Journal Title

      Reproduction, Fertility and Development

      Volume: 22 Pages: 630-641

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Metabolism of radioactive cecium in daily cows2012

    • Author(s)
      Noboru Manabe
    • Journal Title

      Chemistry and Biology

      Volume: 50 Pages: 668-670

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The molecular mechanism of apoptosis upon caspase-8 activation: Quantitative experimental validation of a mathematical model.2012

    • Author(s)
      Katsuya Kominami, Jun Nakabayashi, Takeharu Nagai, Yuki Tsujimura, Kumiko Chiba, Haruna Kimura, Atsushi Miyawaki, Tatsuya Sawasaki, Hideo Yokota, Noboru Manabe, Kazuhiro Sakamaki
    • Journal Title

      Biochimica et Biophysica Acta

      Volume: 1823 Pages: 1825-1840

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Changes in radionuclide levels in milk from the cow supplied with pasture grown in Ibaraki Prefecture, after the accident in Fukushima Daiichi nuclear power plant.2012

    • Author(s)
      Tomotsugu Takahashi, Yuriko Emoto, Maiko Endo, Ichiro Onoyama,Satoru Tomimatsu, Masanori Ikeda, Jun-You Li, Keitaro Tanoi, Tomoko Nakanishi, Noboru Manabe.
    • Journal Title

      Radioisotope

      Volume: 61 Pages: 551-554

    • NAID

      10031127322

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] In vivo imaging of hierarchical spatiotemporal activation of caspase-8 during apoptosis.2012

    • Author(s)
      Katsuya Kominami, Masateru Tsuchimochi, Jun Nishimura, Kumiko Chiba, Jun Nakabayashi, Koji Koyamada, Yaeta Endo, Hideo Yokota, Atsushi Miyawaki, Noboru Manabe
    • Journal Title

      PLoS ONE

      Volume: 7 Pages: 1-18

    • NAID

      120005054550

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Stages of seminiferous epithelium cycle and rate of germ cell apoptosis in adult testis of Japanese native Shiba goat2014

    • Author(s)
      Ahsan AKM Kabir, Yasufumi Goto, Ichiro Onayama, Zubaida Gulshan, Jun-You Li, Noboru Manabe
    • Organizer
      The 16th AAAP Animal Science Congress
    • Place of Presentation
      Yogyakarta, Indonesia
    • Year and Date
      2014-11-10 – 2014-11-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Production of prion gene knockouted cow to prevent spontaneous bovine spongiform encephalopathy2014

    • Author(s)
      Noboru Manabe, Ichiro Onoyama, Tetsuya Tanaka, Jyunyou LI, Kannika Wongpanit, Yutaka Sendai, Yoshito Aoyagi
    • Organizer
      The 16th AAAP Animal Science Congress
    • Place of Presentation
      Yogyakarta, Indonesia
    • Year and Date
      2014-11-10 – 2014-11-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Characteristics of prion KO cow against spontaneous bovine spongiform encephalopathy2014

    • Author(s)
      Noboru Manabe, Ichiro Onoyama, Tetsuya Tanaka, Jyunyou LI, Kannika Wongpanit, Yutaka Sendai, Yoshito Aoyagi.
    • Organizer
      The 11th Annual Meeting of Asian Reproductive Biotecnology Society
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2014-11-03 – 2014-11-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] Changes in expression and localization of cellular flice-like inhibitory protein (cFLIP), an anti-apoptotic factor, in corpora lutea during estrus cycle and pregnancy in Thai swamp buffalo (Bubalus bubalis)2014

    • Author(s)
      Kannika Wongpanit, Panuwat Khumpeerawat, Narisa phonrachom, Pakawadee Pongket, Noboru Manabe
    • Organizer
      The 11th Annual Meeting of Asian Reproductive Biotecnology Society
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2014-11-03 – 2014-11-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] Critical role of decoy receptor 3 in regulation of granulosa cell apoptosis in pig ovarian follicle2014

    • Author(s)
      Yoshinosuke Fukumoto, Miki Sugimoto, Ichiro Onoyama, Kannika Wongpanit, Noboru Manabe
    • Organizer
      The 3rd World Congress of Reproductive Biology
    • Place of Presentation
      Edinburgh, United Kingdom
    • Year and Date
      2014-09-02 – 2014-09-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] Production of prion gene knockout cow to prevent spontaneous bovine spongiform encephalopathy2014

    • Author(s)
      Noboru Manabe, Ichiro Onoyama, Junyou Li, Yutaka Sendai, Yoshito Aoyagi
    • Organizer
      The 3rd World Congress of Reproductive Biology
    • Place of Presentation
      Edinburgh, United Kingdom
    • Year and Date
      2014-09-02 – 2014-09-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] Native pig breeds in focus of reproductive research2014

    • Author(s)
      József Rátky, István Egerszegi, Soukanh Keonuchan, Klaus-Peter Brüssow, Taku Nagai, Kazuhiro Kikuchi, Tamas Somfai, Noboru Manabe
    • Organizer
      International Symposium “Preservation and Utilization of Indigenous Breeds and Their Usage in Pigs”
    • Place of Presentation
      帯広市・日本
    • Year and Date
      2014-08-24 – 2014-08-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Bcl-2 members are involved in granulosa cell apoptosis during follicular atresia in saws2014

    • Author(s)
      Noboru Manabe, Takafumi Sai, Fuko Matsuda, Ichiro Onoyama, Jun-You Li
    • Organizer
      International Symposium on Recent Progress in Swine Breeding and Raising Technologies
    • Place of Presentation
      Tainan, Republic of China (Taiwan)
    • Year and Date
      2014-06-02 – 2014-06-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Cutting edge of bovine reproductive technology: Production of prion gene KO cow to prevent spontaneous BSE2014

    • Author(s)
      Noboru Manabe, Ichiro Onoyama, Yutaka Sendai, Yoshito Aoyagi
    • Organizer
      Symposium of the Thai Society for Animal Reproduction
    • Place of Presentation
      Bngkok, Thailand
    • Year and Date
      2014-04-20 – 2014-04-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Cutting edge of bovine reproductive technology2014

    • Author(s)
      Noboru Manabe, Ichiro Onoyama, Yutaka Sendai, Yoshito Aoyagi
    • Organizer
      The 2nd Joint Symposium of Thai Society for Animal Reproduction and Japanese Society of Reproduction and Development
    • Place of Presentation
      Bangkok, Thailand
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 卵胞顆粒層細胞におけるスカフォールドタンパクp62/SQSTM1の機能発現2014

    • Author(s)
      小野山 一郎、福本善乃助、李 俊佑、眞鍋昇
    • Organizer
      第118回日本畜産学会
    • Place of Presentation
      つくば国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] ブタの卵胞顆粒層細胞と黄体における分化調節因子mRNA発現の排卵前後における推移2014

    • Author(s)
      福本善乃助、小野山 一郎、李 俊佑、眞鍋 昇
    • Organizer
      第118回日本畜産学会
    • Place of Presentation
      つくば国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] ブタ卵巣の卵胞閉鎖と黄体退行の制御における囮受容体3の役割2013

    • Author(s)
      眞鍋昇、小野山一郎、高橋創、福本善乃助、後藤康文、李俊佑、奥田潔
    • Organizer
      第117回日本畜産学会
    • Place of Presentation
      新潟大学
    • Related Report
      2013 Research-status Report
  • [Presentation] シバヤギ顆粒層細胞における抗アポトーシス抑制因子BIRC5(survivin)の発現と役割2013

    • Author(s)
      小野山 一郎、福本善乃助、李 俊佑、眞鍋昇
    • Organizer
      第117回日本畜産学会
    • Place of Presentation
      新潟大学
    • Related Report
      2013 Research-status Report
  • [Presentation] グレリンの顆粒層細胞アポトーシス阻害因子を介した卵胞閉鎖におよぼす影響2013

    • Author(s)
      眞鍋昇、東福望、小野山一郎、福本善乃助、後藤康文、李俊佑
    • Organizer
      第106回日本繁殖生物学会
    • Place of Presentation
      東京農工大学
    • Related Report
      2013 Research-status Report
  • [Presentation] 発生培地へのL-CarnitineおよびEtomoxir添加がウシ体外生産胚の発生率に及ぼす影響2013

    • Author(s)
      高橋利清、ソムファイ・タマス、下司雅也、眞鍋昇
    • Organizer
      第106回日本繁殖生物学会
    • Place of Presentation
      東京農工大学
    • Related Report
      2013 Research-status Report
  • [Presentation] 性腺刺激ホルモンは顆粒層細胞のオートファジーを調節する2013

    • Author(s)
      小野山 一郎、後藤 康文、福本 善乃助、李 俊佑、眞鍋 昇
    • Organizer
      第106回日本繁殖生物学会
    • Place of Presentation
      東京農工大学
    • Related Report
      2013 Research-status Report
  • [Presentation] 卵胞顆粒層細胞に局所性に発現するグレリンはアポトーシス阻害因子を介して卵胞閉鎖に影響する2013

    • Author(s)
      東福望、小野山一郎、福本善乃助、後藤康文、李俊佑、眞鍋昇
    • Organizer
      第156回日本獣医学会
    • Place of Presentation
      岐阜大学
    • Related Report
      2013 Research-status Report
  • [Presentation] オートファゴソームマーカーGFP-LC3を安定発現する顆粒層細胞由来細胞株の作製2013

    • Author(s)
      小野山一郎、後藤康文、福本善乃助、李俊佑、眞鍋昇
    • Organizer
      第156回日本獣医学会
    • Place of Presentation
      岐阜大学
    • Related Report
      2013 Research-status Report
  • [Presentation] High expression of decoy receptor-3 in granulosa cells of Mangalica pig ovaries2013

    • Author(s)
      Noboru Manabe, József Rátky, Keiichi Sezaki, Kennich Ra, Tatsuo Ra, Ichiro Onoyama, Jun-You Li
    • Organizer
      International Conference on Fatty Pig: Science and Utilization of Fatty Pig Breeds
    • Place of Presentation
      Herceghalom, Hungary
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] High expression of Bid in follicular granulosa cells is characteristics in Mangalica ovaries2013

    • Author(s)
      Noboru Manabe, József Rátky, Keiichi Sezaki, Nozomu Toufuku, Ichiro Onoyama,
    • Organizer
      The 2nd Fatty Pig Conference
    • Place of Presentation
      Herceghalom, Hungary
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Production of prion gene homo-KO caws to prevent spontaneous BSE and their characteristics2013

    • Author(s)
      Manabe N, Onoyama I, Li J., Sendai Y, Aoyagi Y
    • Organizer
      The 46th Annual Conference of Physiology and Pathology of Reproduction
    • Place of Presentation
      Gdansk, Poland
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] ブタ卵巣においてグレリンは選択的卵胞閉鎖を抑制する2013

    • Author(s)
      東福望・小野山一郎・李俊佑・眞鍋昇
    • Organizer
      第116回日本畜産学会
    • Place of Presentation
      広島市
    • Related Report
      2012 Research-status Report
  • [Presentation] シバヤギ卵巣におけるオートファジーの観察とヒト顆粒層細胞株を用いたGFP-LC3 安定発現株の樹立2013

    • Author(s)
      小野山一郎・後藤康文・東福望・李俊佑・眞鍋昇
    • Organizer
      第116回日本畜産学会
    • Place of Presentation
      広島市
    • Related Report
      2012 Research-status Report
  • [Presentation] 農場・農産加工廃棄物の好気性超高温発酵処理システムの実用性検討2013

    • Author(s)
      高橋友継・入江猛・李俊佑・大島泰郎・山村正一・眞鍋昇
    • Organizer
      第116回日本畜産学会
    • Place of Presentation
      広島市
    • Related Report
      2012 Research-status Report
  • [Presentation] Roles of decoy receptor 3 in physiological programmed cell death in ovarian follicular granulosa cells2012

    • Author(s)
      N. Manabe, M. Sugimoto, N. Toufuku, H. Gao, A. Kabir, I. Onoyama, J. Li
    • Organizer
      The 15th Asian Animal Science Congress
    • Place of Presentation
      Bangkok, Thailand
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Growth promoting effect of the supplementation of 10 amino acids mixture and rice bran gamma orizanol in calves2012

    • Author(s)
      M. Ikeda, S. Tomimatsu, I. Onoyama, K. Suzuki, J. Li, N. Manabe
    • Organizer
      The 15th Asian Animal Science Congress
    • Place of Presentation
      Bangkok, Thailand
    • Related Report
      2012 Research-status Report
  • [Presentation] T. Takahashi, C Piao, T. Irie, T. J Li, Oshima, S. Yamamura, N. Manabe Novel technology for aerobic ultra-high temperature (110 °C)2012

    • Author(s)
      T. Takahashi, C Piao, T. Irie, T. J Li, Oshima, S. Yamamura, N. Manabe
    • Organizer
      The 15th Asian Animal Science Congress
    • Place of Presentation
      Bangkok, Thailand
    • Related Report
      2012 Research-status Report
  • [Presentation] Mitochondrion-dependent apoptosis pathway is involved in granulosa cell apoptosis which regulates follicular atresia in saws2012

    • Author(s)
      Noboru Manabe, Takafumi Sai, Fuko Matsuda, Naoko Inoue, Yasufumi Goto, Ichiro Onoyama, Junyou Li
    • Organizer
      International Congress on Histochemistry and Cytochemistry
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2012 Research-status Report
  • [Presentation] Bcl-2 members, Bid and Bax, are involved in granulosa cell apoptosis in saws2012

    • Author(s)
      Noboru Manabe, Takafumi Sai, Fuko Matsuda, Ichiro Onoyama, Junyou Li
    • Organizer
      The 17th International Congress on Animal Reproduction
    • Place of Presentation
      Vancouver, Canada
    • Related Report
      2012 Research-status Report
  • [Presentation] Changes in expression and localization of cellular flice-like inhibitory protein (cFLIP), an anti- apoptotic factor, in corpora lutea during estrus cycle and pregnancy in Thai Swamp Buffalo (Bubalus bubalis)2012

    • Author(s)
      Kannika Wongpanit, Panuwat Khumpeerawat, Narisa Phonrachom, Pakawadee Pongket, Noboru Manabe
    • Organizer
      The 17th International Congress on Animal Reproduction
    • Place of Presentation
      Vancouver, Canada
    • Related Report
      2012 Research-status Report
  • [Presentation] Fusion of cytoplasmic fragments to porcine oocytes improves the ability for embryonic development2012

    • Author(s)
      Kazuhiro Kikuchi1, Nguyen Viet Linh1, Michiko Nakai, Hiroyuki Kaneko, Nguyen Thi Men, Nguyen Van Hanh, Tamas Somfai, Bui Xuan Nguyen, Takashi Nagai, Noboru Manabe
    • Organizer
      The 17th International Congress on Animal Reproduction
    • Place of Presentation
      Vancouver, Canada
    • Related Report
      2012 Research-status Report
  • [Presentation] 囮受容体3は黄体退行の制御に関わる2012

    • Author(s)
      眞鍋 昇・高橋 創・小野山 一郎・東福 望・後藤 康文・李 俊佑・奥田 潔
    • Organizer
      第105回日本繁殖生物学会
    • Place of Presentation
      つくば市
    • Related Report
      2012 Research-status Report
  • [Presentation] シバヤギの顆粒層細胞におけるオートファジー関連因子の発現2012

    • Author(s)
      小野山一郎,後藤康文,Kabir AK,高紅梅,東福望,李俊佑,眞鍋昇
    • Organizer
      第105回日本繁殖生物学会
    • Place of Presentation
      つくば市
    • Related Report
      2012 Research-status Report
  • [Presentation] 顆粒層細胞におけるFas誘導性アポトーシス抑制因子のcFLIPに対するグレリンの影響2012

    • Author(s)
      東福望,小野山一郎,高紅梅, Kabir AK,李俊佑,眞鍋昇
    • Organizer
      第105回日本繁殖生物学会
    • Place of Presentation
      つくば市
    • Related Report
      2012 Research-status Report
  • [Presentation] Importance of genetic resources of native pigs in occidental and oriental countries: Practical examples of the characteristics and utilization of native pigs in Hungary and Laos

    • Author(s)
      J. Rátky, I. Egerszegi, P. Toth, S. Keonuchan, K-P. Brüssow, T. Nagai, K. Kikuchi, N. Manabe
    • Organizer
      The 15th Asian Animal Science Congress
    • Place of Presentation
      Bangkok, Thailand
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] 獣医組織学第6版・第14章雌の生殖器2014

    • Author(s)
      眞鍋昇, 木村順平, 大塚沙織
    • Total Pages
      364
    • Publisher
      学窓社
    • Related Report
      2014 Annual Research Report
  • [Book] 繁殖生物学(第2章生殖細胞と生殖器)2013

    • Author(s)
      眞鍋昇
    • Total Pages
      313
    • Publisher
      インターズー
    • Related Report
      2013 Research-status Report
  • [Book] 牛病学(第11章非感染性疾病・放牧病)2013

    • Author(s)
      眞鍋昇
    • Total Pages
      412
    • Publisher
      近代出版
    • Related Report
      2013 Research-status Report
  • [Book] 東日本大震災からの農林水産業と地域社会の復興(シリーズ21世紀の農2013

    • Author(s)
      眞鍋昇, 高橋友継, 小野山一郎, 遠藤麻衣子, 飯塚祐彦, 李俊佑, 田野井慶太朗, 中西友子
    • Total Pages
      138
    • Publisher
      養賢堂
    • Related Report
      2013 Research-status Report
  • [Book] The Senescence-Accelerated Mouse (SAM): Achievements and Future Directions Section II.2013

    • Author(s)
      Noboru Manabe, Kannika Wongpanit, Hua-Zi Jin, Kazumi Taniguchi, Xin Jin
    • Total Pages
      204
    • Publisher
      Elsevier Science
    • Related Report
      2013 Research-status Report
  • [Book] Agricultural Implications of the Fukushima Nuclear Accident Chapter 9.2013

    • Author(s)
      Noboru Manabe, Tomotusugu Takahashi, Jun-You Li, Keitaro Tanoi, Tomoko M. Nakanishi
    • Total Pages
      204
    • Publisher
      Springer
    • Related Report
      2013 Research-status Report
  • [Book] ウシの解剖アトラス第2版2013

    • Author(s)
      眞鍋昇
    • Total Pages
      138
    • Publisher
      緑書房
    • Related Report
      2013 Research-status Report
  • [Book] Agricultural Implications of the Fukushima Nuclear Accident2013

    • Author(s)
      Noboru Manabe , Tomotsugu Takahashi , Junyou Li , Keitaro Tanoi, Tomoko Nakanishi
    • Total Pages
      204
    • Publisher
      Springer
    • Related Report
      2012 Research-status Report
  • [Remarks] 東京大学大学院農学生命科学研究科附属牧場

    • URL

      http://www.bokujo.a.u-tokyo.ac.jp/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 東京大学農学部附属牧場

    • URL

      http://www.bokujo.a.u-tokyo.ac.jp/

    • Related Report
      2013 Research-status Report
  • [Remarks] 東京大学附属牧場

    • URL

      http://park.itc.u-tokyo.ac.jp/bokujo/

    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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