Rescue of potential oocytes in livestock ovaries by artificial control of apoptosis inhibitor
| Project/Area Number |
24658231
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied animal science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MANABE Noboru 東京大学, 農学生命科学研究科, 教授 (80243070)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | アポトーシス / アポトーシス阻害因子 / 卵巣内潜在的卵母細胞 / 家畜卵巣 / 卵胞 / 顆粒層細胞 / 細胞死リガンド・受容体系 / カスパーゼ系 / 卵巣 / 卵巣内潜在的卵子 / カスパーゼ / 卵子救済 / 卵胞選抜 / 哺乳類 / 発現制御 |
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| Outline of Final Research Achievements |
Many primordial follicles in livestock ovaries are discarded without being effectively used in the slaughterhouse. The aim of my study is to save the oocytes with excellent genetic traits in the ovaries, which are discarded without being effectively used. Less than 1% of primordial follicles are ovulated, and the remainders are eliminated via atresia. The precise mechanisms involved in the regulation of follicule selection remain unknown. Recent my studies suggest that apoptosis in follicular granulosa cells plays a crucial role in the oocyte selection. Cell death ligand and receptor systems are the key mechanisms regulating granulosa cell apoptosis. I revealed the roles of intracellular apoptosis inhibitory factors (cFLIP, XIAP, DcR3 etc.), which are useful to assess the damaged and/or healthy oocytes and save the oocyte including the follicle. Then, I have developed a method to save the oocyte with the help of these inhibitors.
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Report
(4 results)
Research Products
(74 results)
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[Journal Article] Hallmarks of hepatitis C virus in equine hepaciviru2014
Author(s)
6.Tomohisa Tanaka, Hirotake Kasai, Atsuya Yamashita, Kaori Okuyama-Dobashi, Jun Yasumoto, Shinya Maekawa, Nobuyuki Enomoto, Toru Okamoto, Yoshiharu Matsuura, Masami Morimatsu, Noboru Manabe, Kazuhiko Ochiai, Kazuto Yamashita, Kohji Moriishi
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Journal Title
Journal of Virology
Volume: 88
Pages: 13352-13366
Related Report
Peer Reviewed / Open Access
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[Journal Article] The molecular mechanism of apoptosis upon caspase-8 activation: Quantitative experimental validation of a mathematical model.2012
Author(s)
Katsuya Kominami, Jun Nakabayashi, Takeharu Nagai, Yuki Tsujimura, Kumiko Chiba, Haruna Kimura, Atsushi Miyawaki, Tatsuya Sawasaki, Hideo Yokota, Noboru Manabe, Kazuhiro Sakamaki
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Journal Title
Biochimica et Biophysica Acta
Volume: 1823
Pages: 1825-1840
Related Report
Peer Reviewed
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[Journal Article] Changes in radionuclide levels in milk from the cow supplied with pasture grown in Ibaraki Prefecture, after the accident in Fukushima Daiichi nuclear power plant.2012
Author(s)
Tomotsugu Takahashi, Yuriko Emoto, Maiko Endo, Ichiro Onoyama,Satoru Tomimatsu, Masanori Ikeda, Jun-You Li, Keitaro Tanoi, Tomoko Nakanishi, Noboru Manabe.
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Journal Title
Radioisotope
Volume: 61
Pages: 551-554
NAID
Related Report
Peer Reviewed
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[Presentation] Native pig breeds in focus of reproductive research2014
Author(s)
József Rátky, István Egerszegi, Soukanh Keonuchan, Klaus-Peter Brüssow, Taku Nagai, Kazuhiro Kikuchi, Tamas Somfai, Noboru Manabe
Organizer
International Symposium “Preservation and Utilization of Indigenous Breeds and Their Usage in Pigs”
Place of Presentation
帯広市・日本
Year and Date
2014-08-24 – 2014-08-25
Related Report
Invited
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[Presentation] T. Takahashi, C Piao, T. Irie, T. J Li, Oshima, S. Yamamura, N. Manabe Novel technology for aerobic ultra-high temperature (110 °C)2012
Author(s)
T. Takahashi, C Piao, T. Irie, T. J Li, Oshima, S. Yamamura, N. Manabe
Organizer
The 15th Asian Animal Science Congress
Place of Presentation
Bangkok, Thailand
Related Report
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[Presentation] Fusion of cytoplasmic fragments to porcine oocytes improves the ability for embryonic development2012
Author(s)
Kazuhiro Kikuchi1, Nguyen Viet Linh1, Michiko Nakai, Hiroyuki Kaneko, Nguyen Thi Men, Nguyen Van Hanh, Tamas Somfai, Bui Xuan Nguyen, Takashi Nagai, Noboru Manabe
Organizer
The 17th International Congress on Animal Reproduction
Place of Presentation
Vancouver, Canada
Related Report
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