Research on the mechanism of disease progression of bovine leukemia virus-induced lymphoma in young cattle
| Project/Area Number |
24658241
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Hokkaido University |
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Principal Investigator |
KONNAI SATORU 北海道大学, (連合)獣医学研究科, 准教授 (40396304)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 牛白血病 / 牛白血病ウイルス / 散発型牛白血病 / 子牛型牛白血病 / 地方病型牛白血病 / リンパ腫 / BLV / 若齢牛 / 子牛型白血病 / 地方病型白血病 |
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| Research Abstract |
The bovine leukemia virus (BLV) causes malignant B-cell lymphoma after a long latent period. A growing number of cases of the lymphoma in young cattle have been reported in recent years. However, many aspects of the BLV-induced lymphoma are still poorly understood. In this study, it was observed that IgM high expressing-B cells were increased in number in blood from BLV-infected cattle, and were prone to express BLV antigens as compared to IgM low expressing-B cells. IgM low expressing-B cells showed higher expression levels of the Tax/Rex mRNA, PD-L1 and some proto oncogenes (e. g. Maf, Jun and Fos). Indeed, IgM low expressing-B cells or IgM nagative B cells were major cell populations in the lymphoma from BLV-infected cattle in clinical cases (n=14), meanwhile IgM high expressing-B cells were very few. These data indicated that IgM low expressing-B cells are superior to evade from immune surveillance system and to become neoplastic clones.
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Report
(3 results)
Research Products
(106 results)
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[Journal Article] Enhanced expression of LAG-3 on lymphocyte subpopulations from persistently lymphocytotic cattle infected with bovine leukemia virus2013
Author(s)
Konnai, S., Suzuki, S., Shirai, T., Ikebuchi, R., Okagawa, T., Sunden., Y, Mingala C.N., Onuma, M., Murata, S., Ohashi K.
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Journal Title
Comp Immunol Microbiol Infect Dis.
Volume: 36
Issue: 1
Pages: 63-9
DOI
Related Report
Peer Reviewed
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[Journal Article] Increased bovine Tim-3 and its ligand expressions during bovine leukemia virus infection2012
Author(s)
Okagawa, T., Konnai, S., Ikebuchi, R., Suzuki, S., Shirai, T., Sunden, Y., Onuma M., Murata, S., Ohashi, K.
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Journal Title
Vet. Res.
Volume: 43
Issue: 1
Pages: 45-45
DOI
Related Report
Peer Reviewed
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[Presentation] 牛白血病の対策について2013
Author(s)
今内覚
Organizer
北海道獣医師会留萌支部平成25年度新技術講習会
Place of Presentation
北海道留萌家畜保健衛生所(幌延町)
Year and Date
2013-09-27
Related Report
Invited
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[Presentation] 牛白血病の対策について2013
Author(s)
今内覚
Organizer
北海道獣医師会牛白血病対策検討委員会
Place of Presentation
北海道獣医師会館(札幌市)
Year and Date
2013-03-26
Related Report
Invited
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[Presentation] 牛の白血病について2012
Author(s)
今内覚
Organizer
北海道獣医師会胆振支部特別講演
Place of Presentation
苫小牧農協(苫小牧市)
Year and Date
2012-11-30
Related Report
Invited
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[Presentation] 牛白血病の現状と対策2012
Author(s)
今内覚
Organizer
埼玉県獣医師会特別講演
Place of Presentation
熊谷家畜保健衛生所(熊谷市)
Year and Date
2012-10-19
Related Report
Invited
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[Presentation] 牛の白血病について2012
Author(s)
今内覚
Organizer
北海道獣医師会根室支部特別講演
Place of Presentation
根室地区NOSAI中標津支所(中標津町)
Year and Date
2012-05-14
Related Report
Invited
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