| Project/Area Number |
24658241
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Hokkaido University |
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Principal Investigator |
KONNAI SATORU 北海道大学, (連合)獣医学研究科, 准教授 (40396304)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 牛白血病 / 牛白血病ウイルス / 散発型牛白血病 / 子牛型牛白血病 / 地方病型牛白血病 / リンパ腫 / BLV / 若齢牛 / 子牛型白血病 / 地方病型白血病 |
|---|
| Research Abstract |
The bovine leukemia virus (BLV) causes malignant B-cell lymphoma after a long latent period. A growing number of cases of the lymphoma in young cattle have been reported in recent years. However, many aspects of the BLV-induced lymphoma are still poorly understood. In this study, it was observed that IgM high expressing-B cells were increased in number in blood from BLV-infected cattle, and were prone to express BLV antigens as compared to IgM low expressing-B cells. IgM low expressing-B cells showed higher expression levels of the Tax/Rex mRNA, PD-L1 and some proto oncogenes (e. g. Maf, Jun and Fos). Indeed, IgM low expressing-B cells or IgM nagative B cells were major cell populations in the lymphoma from BLV-infected cattle in clinical cases (n=14), meanwhile IgM high expressing-B cells were very few. These data indicated that IgM low expressing-B cells are superior to evade from immune surveillance system and to become neoplastic clones.
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