| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Research Abstract |
We here investigated the pathophysiological role of vascular endothelial cell-derived micro-particle. We found that 1) stimulations by Ca2+ ionophore or inflammatory cytokines make endothelial cells to produce microparticle (about 50-100 nm diameter), 2) the endothelial micro-particles produces various types of prostaglandins, and 3) administration of micro-particles modulate inflammatory responses both in vitro and vivo. These observations revealed the novel role of vascular endothelial cells in inflammation.
|
