A role for Annexin A5 in the pregnancy
| Project/Area Number |
24658249
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | アネキシンA5 / 不育症 / 血小板 / 凝固 / 抗リン脂質症候群 |
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| Research Abstract |
Annexin A5 (Anxa5) is a calcium dependent phospholipid binding protein and a member of annexin family proteins. While it has been assumed that Anxa5 would be involved in the anticoagulant action in the placenta, there has no direct evidence. We have demonstrated that Anxa5 has a crucial role in the anticoagulation during pregnancy by using Anxa5 knockout mice. We confirmed that aggregation of platelets occurred in the placenta of Anxa5KO. We have reported this already (Sci, Rep. 2. 827).
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Report
(3 results)
Research Products
(20 results)
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[Journal Article] Loss of maternal annexin A5 increases the likelihood of Placental platelet thrombosis and foetal loss2012
Author(s)
Ueki H, Mizushina T, Laharatchatathanin T, Terashima R, Nishimura Y, Rieanrakwong D, Yonezawa T, Kurusu S, Hasegawa Y, Brachyogel B, Poschl E, Kawaminami M
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Journal Title
Scientific reports
Volume: 2
Issue: 1
Pages: 827-827
DOI
Related Report
Peer Reviewed
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