A role for Annexin A5 in the pregnancy

• Project/Area Number: 24658249
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Basic veterinary science/Basic zootechnical science
• Research Institution: Kitasato University
• Principal Investigator: KAWAMINAMI Mitsumori 北里大学, 獣医学部, 教授 (00153007)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: アネキシンA5 / 不育症 / 血小板 / 凝固 / 抗リン脂質症候群

Research Abstract

Annexin A5 (Anxa5) is a calcium dependent phospholipid binding protein and a member of annexin family proteins. While it has been assumed that Anxa5 would be involved in the anticoagulant action in the placenta, there has no direct evidence. We have demonstrated that Anxa5 has a crucial role in the anticoagulation during pregnancy by using Anxa5 knockout mice. We confirmed that aggregation of platelets occurred in the placenta of Anxa5KO. We have reported this already (Sci, Rep. 2. 827).

Research Products

• [Journal Article] Loss of maternal annexin A5 increases the likelihood of Placental platelet thrombosis and foetal loss (2012)
  • Author(s): Ueki H, Mizushina T, Laharatchatathanin T, Terashima R, Nishimura Y, Rieanrakwong D, Yonezawa T, Kurusu S, Hasegawa Y, Brachyogel B, Poschl E, Kawaminami M
  • Journal Title: Scientific reports Volume: 2 Issue: 1 Pages: 827-827
  • DOI: 10.1038/srep00827
  • Peer Reviewed
• [Presentation] アネキシンA5ノックアウトマウスの黄体形成ホルモン(LH)分泌 (2013)
  • Author(s): 小野寺桃子,水品智菜,尾崎優,武藤顕一郎,米澤智洋,久留主志朗,汾陽光盛
  • Organizer: 第156回日本獣医学会
  • Place of Presentation: 岐阜市(岐阜県)
  • Year and Date: 2013-09-20
• [Presentation] ラット発情前期の黄体形成ホルモン(LH)サージに伴う下垂体前葉でのアネキシンA5の変化 (2013)
  • Author(s): 汾陽光盛,中村祐希,米澤智洋,久留主志朗
  • Organizer: 第156回日本獣医学会
  • Place of Presentation: 岐阜市(岐阜県)
  • Year and Date: 2013-09-20
• [Presentation] アネキシンA5ノックアウトマウスの黄体形成ホルモン（LH)分泌 (2013)
  • Author(s): 小野寺桃子, 水品智菜, 尾崎 優, 武藤顕一郎, 米澤智洋, 久留主志朗, 汾陽光盛
  • Organizer: 第156回日本獣医学会
  • Place of Presentation: 岐阜大学（岐阜）
• [Presentation] ラット発情前期の黄体形成ホルモン（LH)サージに伴う下垂体前葉でのアネキシンA5の変化 (2013)
  • Author(s): 汾陽光盛, 中村祐希, 米澤智洋, 久留主志朗
  • Organizer: 第156回日本獣医学会
  • Place of Presentation: 岐阜大学（岐阜）
• [Presentation] Specific distribution of Annexin A5 in the hypothalamus and possible relationship to altered behavior of Annexin A5 null mouse (2013)
  • Author(s): Yonezawa T, Motoh K-I, Shindo J, Kurusu S, Brachvogel B, Poschl E, Kawaminami M
  • Organizer: 7th International Conference on Annexins
  • Place of Presentation: London, England
• [Presentation] 黄体形成ホルモン（LH）分泌に伴うゴナドトロフ内アネキシンA5の局在 (2013)
  • Author(s): 汾陽光盛, 中村祐希, 米澤智洋, 久留主志朗
  • Organizer: 第28回日本下垂体研究会
  • Place of Presentation: ホテル千秋閣（花巻、岩手）
• [Presentation] Pre-ovulatory augmentation of metastin mRNA expression in follicles of rats (2013)
  • Author(s): Laoharatchatathanin T, Terashima R, Yonezawa T, Kurusu S, Kawaminami M
  • Organizer: The Endocrine Society's 95th Annual Meeting
  • Place of Presentation: Moscome Center（San Francisco,USA）
• [Presentation] Annexin A5 of maternal blood is prerequisite for preventing fetal loss during intact pregnancy (2012)
  • Author(s): Kawaminami M, Ueki H, Nidhimuts Y, Rieanrakwong D, Yonezawa T, Kurusu S
  • Organizer: The Endocrine Society's 94th Annual Meeting
  • Place of Presentation: Houston, Texas, USA
  • Year and Date: 2012-06-24
• [Presentation] げっ歯類の雄性生殖におけるGroup IVA phospholipase A2の役割
  • Author(s): 久留主志朗
  • Organizer: 日本脂質生化学会
  • Place of Presentation: 福岡県福岡市 九州大学
• [Presentation] 抗ウイルス遺伝子myxovirus resistance 1 (Mx1)変異体の細胞増殖抑制作用
  • Author(s): 寺島涼太
  • Organizer: 第27回日本下垂体研究会
  • Place of Presentation: 山形県天童市 天童ホテル
• [Presentation] アネキシンA5ノックアウトマウスの下垂体機能について
  • Author(s): 汾陽光盛
  • Organizer: 第27回日本下垂体研究会
  • Place of Presentation: 山形県天童市 天童ホテル
• [Presentation] アネキシンA5欠損の胎盤循環への影響と産仔数の減少
  • Author(s): 水品智菜
  • Organizer: 第105回日本繁殖生物学会
  • Place of Presentation: 茨城県つくば市 筑波大学
• [Presentation] LH surge induces metastin expression in preovulatory follicles of rats
  • Author(s): Laoharatchatathanin T
  • Organizer: 第105回日本繁殖生物学会
  • Place of Presentation: 茨城県つくば市 筑波大学
• [Presentation] ゴナドトロピン放出ホルモン（GnRH）による抗ウイルス遺伝子myxovirus resistance 1（Mx1）mRNA発現の変動
  • Author(s): 寺島涼太
  • Organizer: 第154回日本獣医学会
  • Place of Presentation: 岩手県盛岡市 岩手大学
• [Presentation] The GnRH-Independent effect of metastin on gonadotropin release and behavior in hypogonadal mice
  • Author(s): Yonezawa T
  • Organizer: The Endocrine Society's 94th Annual Meeting
  • Place of Presentation: Houston, Texas, USA, George R. Brown Convention Center
• [Presentation] Annexin A5 of maternal blood is prerequisite for preventing fetal loss during intact pregnancy
  • Author(s): Kawaminami M
  • Organizer: The Endocrine Society's 94th Annual Meeting
  • Place of Presentation: Houston, Texas, USA, George R. Brown Convention Center
• [Presentation] Interferon (IFN) alpha stimulates the accumulation of Myxovirus (influenza virus) resistance 1 (Mx1) pseudo-gene transcripts including an intron-containing transcript in mouse pituitary gonadotropes
  • Author(s): Terashima R
  • Organizer: The Endocrine Society's 95th Annual Meeting
  • Place of Presentation: SanFrancisco, CA, USA, The Moscone Center
• [Presentation] Pre-ovulatory augmentation of metastin mRNA expression in follicles of rats
  • Author(s): Laoharatchatathanin T
  • Organizer: The Endocrine Society's 95th Annual Meeting
  • Place of Presentation: SanFrancisco, CA, USA, The Moscone Center
• [Patent(Industrial Property Rights)] 細胞増殖抑制剤 (2012)
  • Inventor(s): 汾陽光盛
  • Industrial Property Rights Holder: 学校法人北里研究所
  • Industrial Property Rights Type: 特許
  • Acquisition Date: 2012-07-06
  • Overseas