| Project/Area Number |
24658253
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied veterinary science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
GOTO Yasuyuki 東京大学, 農学生命科学研究科, 准教授 (50553434)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUMOTO Yoshitsugu 東京大学, 大学院農学生命科学研究科, 教授 (00173922)
YAMAGISHI Junya 東北大学, メディカルメガバンク機構, 助教 (80535328)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | ワクチン / 細胞性免疫 / in silico解析 / リーシュマニア症 / Reverse vaccinology / 抗原 |
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| Research Abstract |
Identification of parameters influencing the effectiveness of vaccine antigens for leishmaniasis was searched in this study. Statistical analyses revealed amino acid composition, expression level, and localization to exosome were influential parameters. A formula based on the three parameters discriminated the previously characterized vaccine antigens from the whole proteome. Furthermore, novel antigens identified using the formula were as antigenic as the known antigens. These results suggest the in silico approach developed is useful to identify candidate vaccine antigens for leishmaniasis.
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