The research on flavivirus organ-tropism
| Project/Area Number |
24658261
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied veterinary science
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| Research Institution | Kyoto Sangyo University |
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Principal Investigator |
MAEDA Akihiko 京都産業大学, 総合生命科学部, 教授 (70333359)
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| Co-Investigator(Kenkyū-buntansha) |
SASAKI Nobuya 北里大学, 獣医学部, 教授 (20302614)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 感染症 / フラビウイルス / スライス培養 / 臓器特異性 / ウイルス / 獣医学 / 細胞・組織 / 臓器 / ウエストナイルウイルス / ウイルス様粒子 |
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| Research Abstract |
In order to solidify organ-tropisms of pathogenic microbes, we conducted the experiments as described below, using a neurotropic flavivirus as a model of infectious agent. First, flavivirus reporter virus particles (RVPs) encoding the red-fluorescent protein gene within its genome RNA, were prepared to be visible virus infections. Next, mouse brain slice-culture system was established to analyze organ-tropism of the virus easily. Finally, flavivirus RVPs-infection system on mouse brain slice-cultures was established. We might apply the system to do research on organ-tropism of pathogenic microbes.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] A. The chicken 2-5 oligoadenylate synthetase A inhibits the replication of West Nile Virus2012
Author(s)
Tag-El-din-Hassan, Hassan T., Sasaki, N., Moritoh, K., Torigoe, D., Maeda, A., and Takashi
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Journal Title
Jap. J. Vet. Res
Volume: 60
Pages: 95-103
NAID
Related Report
Peer Reviewed
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[Journal Article] The chicken 2-5 oligoadenylate synthetase A inhibits the replication of West Nile Virus.2012
Author(s)
Tag-El-din-Hassan, Hassan T., Sasaki, N., Moritoh, K., Torigoe, D., Maeda, A., and Agui, T.
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Journal Title
Jap. J. Vet. Res.
Volume: 60
Pages: 95-103
NAID
Related Report
Peer Reviewed
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[Presentation] Effects of land use pattern on spatial distribution of host-seeking mosquitoes within urban areas in Kyoto, Japan2013
Author(s)
Yonejima, M., Nakaya, T., Nihei, N., Tsuda, Y., Koboyashi, M., Watanabe, M. and Maeda, A
Organizer
International Geographic Union, Kyoto Regional Conference
Place of Presentation
Kyoto
Related Report
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[Presentation] Effects of land use pattern on spatial distribution of host-seeking mosquitoes within urban areas in Kyoto, Japan.2013
Author(s)
Yonejima, M., Nakaya, T., Nihei, N., Tsuda, Y., Kobayashi, M., Watanabe, M., and Maeda, A.
Organizer
International Geographic Union
Place of Presentation
Kyoto，京都国際会館
Related Report
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