Is "steric hindrance effect" the possible new concept for tumor metastasis mechanism?
Project/Area Number |
24658268
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Single-year Grants |
Research Field |
Clinical veterinary science
|
Research Institution | Yamaguchi University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
NAKAGAWA Takayuki 東京大学, 農学部, 助教 (40447363)
KUBO Masato 山口大学, 共同獣医学部, 助教 (40593439)
|
Project Period (FY) |
2012-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | PSGL-1 / 犬 / 腫瘍 |
Research Abstract |
The effect of PSGL-1 expression on tumor cells on tumor metastasis was examined. Canine PSGL-1 was not detected in naturally occurred canine solid tumor by immunohistochemistry, but was detected in canine lymphoma samples. Injection of canine lymphoma cell lines which has lower level of PSGL1 by knockdown technique into NOJ mice had lower rate of metastasis as compared with parental lymphoma cell lines. Canine mammary gland tumor cell lines overexrpressing PSGL-1 into NOD/SCID mice appeared to have more lung metastasis. In conclusion, this study indicated that PSGL-1 has an important role in tumor metastasis or dissemination.
|
Report
(3 results)
Research Products
(31 results)
-
-
-
[Journal Article] Oncolytic reovirus in canine mast cell tumor2013
Author(s)
Hwang CC, Umeki S, Kubo M, Hayashi T, Shimoda H, Mochizuki M, Maeda K, Baba K, Hiraoka H, Coffey M, Okuda M, Mizuno T
-
Journal Title
Related Report
Peer Reviewed
-
-
-
[Journal Article] Vaccination with antigen-transfected, NKT cell ligand-loaded, human cells elicits robust in situ immune responses by dendritic cells2013
Author(s)
Shimizu K, Mizuno T, Shinga J, Asakura M, Kakimi K, Ishii Y, Masuda K, Maeda T, Sugahara H, Sato Y, Matsushita H, Nishida K, Hanada KI, Dörrie J, Schaft N, Bickham K, Koike H, Ando T, Nagai R, Fujii SI
-
Journal Title
Cancer Res
Volume: 73(1)
Pages: 62-73
Related Report
Peer Reviewed
-
-
[Journal Article] Establishment of Five Canine Lymphoma Cell Lines and Tumor Formation in a Xenotransplantation Model.2013
Author(s)
Umeki S, Ema Y, Suzuki R, Kubo M, Hayashi T, Okamura Y, Yamazaki J, Tsujimoto H, Tani K, Hiraoka H, Okuda M, Mizuno T.
-
Journal Title
NAID
Related Report
Peer Reviewed
-
[Journal Article] Establishment of Five Canine Lymphoma Cell Lines and Tumor Formation in a Xenotransplantation Model2012
Author(s)
Umeki S, Ema Y, Suzuki R, Kubo M, Hayashi T, Okamura Y, Yamazaki J, Tsujimoto H, Tani K, Hiraoka H, Okuda M, Mizuno T
-
Journal Title
NAID
Related Report
Peer Reviewed
-
-
[Journal Article] Feline infectious peritonitis virus with a large deletion in the 5'-terminal region of the spike gene retains its virulence for cats2012
Author(s)
Terada Y, Shiozaki Y, Shimoda H, Mahmoud HY, Noguchi K, Nagao Y, Shimojima M, Iwata H, Mizuno T, Okuda M, Morimoto M, Hayashi T, Tanaka Y, Mochizuki M, Maeda K
-
Journal Title
J Gen Virol
Volume: 93(Pt 9)
Pages: 1930-934
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-