| Project/Area Number |
24658284
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
NISHIKAWA Atsushi 東京農工大学, (連合)農学研究科(研究院), 教授 (30218127)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ボツリヌス毒素 / ドラッグ・デリバリー・システム / ドラッグデリバリーシステム |
|---|
| Research Abstract |
Botulinum progenitor toxin consists of one neurotoxin (NTX) and multiple non-toxic components including several haemagglutinin (HA) proteins. Orally ingested NTX passes through the epithelial layer into the blood circulation system with the aide of HA components, and specifically binds to the peripheral nerve cells, and invades into cytoplasm, then causes food-borne botulism. In this study, we challenged the development of novel drug delivery system (DDS) utilizing the botulinum tactical infection mechanism, and a several results which provide a platform for novel DDS were obtained.
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