| Project/Area Number |
24659011
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
AOKI Shin 東京理科大学, 薬学部, 教授 (00222472)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | リン酸化 / 脱リン酸化 / ロタキサン / 超分子 / 酵素反応 / 分子機械 |
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| Research Abstract |
Molecular motors such as ATP synthetase are so-called "molecular motors" that utilize chemical bonding energy of ATP. The purpose of this project is to design and synthesize artificial supramolecular complexes, the structure of which are altered by enzymatic phosphorylation and dephosphorylation reactions. We have designed the rotaxane-like supramoleculer complexes that contain a macrocycle part (cyclodextrin (CyD)) and an axis part that is threaded through a CyD ring. In this work, we have succeed in the synthesis of the rotaxane molecule that contains an azobenzene unit as "Station " at the center of the axis and two Zn2+-cyclen complex units as "Station 2" at the edge of the axis.
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