Research Project
Grant-in-Aid for Challenging Exploratory Research
In order to develop specific molecular probes for in vivo imaging of P-glycoprotein, an X-ray crystallographic analysis of a P-glycoprotein homolog in complex with some candidate molecules for the probe was performed and the structural basis of their interactions was elucidated. From the X-ray diffraction analysis clear electron density of the P-glycoprotein homolog was observed whereas the unclear density of the probe molecules was detected. A photometric assay of the complex crystals indicated that the probes were included in the crystals. These findings indicated that the probe candidates are weakly bound in the inner cavity of the P-glycoprotein homolog and their conformations are unfixed even in the crystalline state.
All 2014 2013 2012
All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (12 results) (of which Invited: 6 results)
Proceedings of the National Academy of Sciences of the United States of America
Volume: 111 Issue: 11 Pages: 4049-4054
10.1073/pnas.1321562111
