| Project/Area Number |
24659021
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Physical pharmacy
|
|---|
| Research Institution | University of Shizuoka |
|---|
Principal Investigator |
OKU NAOTO 静岡県立大学, 薬学部, 教授 (10167322)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ASAI Tomohiro 静岡県立大学, 薬学部, 准教授 (00381731)
SHIMIZU Kosuke 静岡県立大学, 薬学部, 助教 (30423841)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 薬学 / 長期血中滞留性 / 薬物送達システム / リポソーム / ファージディスプレイペプチドライブラリー / バイオパニング / ドラッグデリバリー / ＤＤＳ |
|---|
| Research Abstract |
In the development of drug nanocarriers in drug delivery systems or recombinant protein medicines, rapid blood clearance of these is frequently problematic. To overcome this rapid clearance, we attemped to obtain petides having long circulating characteristic by use of phage-displayed peptide library that presenting 5 mer random peptides. After intravenous injection of the library, we selected long circulating phages and identified long circulating peptides. Unfortunately, the circulating characteristics of drug nanocarriers was not improved by modifying the surface of them with the peptides. However, since cloned phages presenting these peptids showed quite long circulation in the bloodsteam of mice, we believe that these peptides are useful for the development of DDS drugs or protein drugs.
|
