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Development of novel on-site analysis of urinary selenometabolites

Research Project

Project/Area Number 24659022
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Physical pharmacy
Research InstitutionShowa Pharmaceutical University

Principal Investigator

OGRA Yasumitsu  昭和薬科大学, 薬学部, 教授 (40292677)

Co-Investigator(Kenkyū-buntansha) ANAN Yasumi  昭和薬科大学, 薬学部, 講師 (40403860)
TOKUMOTO Maki  昭和薬科大学, 薬学部, 助教 (90614339)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsセレン / ICP-MS / セレン糖 / 表面プラズモン共鳴 / スペシエーション / 尿 / テルル
Research Abstract

In this project, we intended to establish a novel technique for detection of urinary selenosugar by lectins. Three lectins, i.e., soybean lectin, lectin from Dolichos biflorus and wheat germ agglutinin were used on the basis of their sugar specificities. No interactions between selenosugar and the lectins were detected by an LC-inductively coupled plasma-mass spectrometer and a detector of surface plasmon resonance (Biacore). As expected initially, the aim of this study was very challenging but suitable for a feasibility study. In addition, during the sample preparation, a novel selenium metabolite, selenocyanate, was detected and identified in biological samples.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (79 results)

All 2014 2013 2012 Other

All Journal Article (16 results) (of which Peer Reviewed: 14 results) Presentation (55 results) (of which Invited: 8 results) Book (5 results) Remarks (3 results)

  • [Journal Article] An improved tolerance to cadmium by overexpression of two genes for cysteine synthesis in tobacco2014

    • Author(s)
      M. Nakamura, T. Ochiai, M. Noji, Y. Ogra, K.T. Suzuki, N. Yoshimoto, M. Yamazaki, K. Saito
    • Journal Title

      Plant Biotech

      Volume: (in press)

    • NAID

      130003391375

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 哺乳類細胞における銅の恒常性維持の分子機構2014

    • Author(s)
      小椋康光
    • Journal Title

      日本衛生学会誌

      Volume: 69 Pages: 136-145

    • NAID

      130004776102

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cooperative functions of ZnT1, metallothionein and ZnT4 in the cytoplasm are required for full2013

    • Author(s)
      Fujimoto S, Kimura T, Nagao M and Kambe T, et al. (11人中11番目)
    • Journal Title

      PLOS ONE

      Volume: 8 Issue: 10 Pages: e77445-e77445

    • DOI

      10.1371/journal.pone.0077445

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Speciation and identification of tellurium-containing metabolites in garlic2013

    • Author(s)
      Y. Anan, M. Yoshida, S. Hasegawa, R. Katai, M. Tokumoto, L. Ouerdane, R. Łobiński and Y. Ogra
    • Journal Title

      Allium sativum. Metallomics

      Volume: 5 Issue: 9 Pages: 1215-1224

    • DOI

      10.1039/c3mt00108c

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Behavior of selenoproteins in rat serum detected by inductively coupled plasma mass spectrometry2013

    • Author(s)
      Y. Anan, Y. Hatakeyama, M. Tokumoto and Y. Ogra
    • Journal Title

      Anal. Sci.

      Volume: 29 Pages: 787-792

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of animal and plant selenometabolites in roots of a selenium accumulator2013

    • Author(s)
      Y. Ogra, A. Katayama, Y. Ogihara, A. Yawata and Y. Anan
    • Journal Title

      Brassica rapa var. peruviridis, by speciation. Metallomics

      Volume: 5 Issue: 5 Pages: 429-436

    • DOI

      10.1039/c2mt20187a

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Toxicological and pharmacological analysis of selenohomolanthionine in mice2013

    • Author(s)
      Y. Anan and Y. Ogra
    • Journal Title

      Toxicol. Res.

      Volume: 2 Pages: 115-122

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] スペシエーションによるセレン及びテルルのメタボローム解析2013

    • Author(s)
      小椋康光
    • Journal Title

      生化学

      Volume: 85 Pages: 519-530

    • NAID

      10031190081

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 「誘導結合プラズマ発光分光分析法及び誘導結合プラズマ質量分析法」について2013

    • Author(s)
      小椋康光、四方田千佳子
    • Journal Title

      日本薬局方フォーラム

      Volume: 22 Pages: 674-676

    • Related Report
      2013 Final Research Report
  • [Journal Article] Chromatographic behavior of selenoproteins in rat serum detected by inductively coupled plasma mass spectrometry.2013

    • Author(s)
      Anan Y, Hatakeyama Y, Tokumoto M, Ogra Y
    • Journal Title

      Anal. Sci.

      Volume: 29 Pages: 787-792

    • NAID

      10031190632

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Toxicological and pharmacological analysis of selenohomolanthionine in mice.2013

    • Author(s)
      Anan Y, Ogra Y
    • Journal Title

      Toxicol. Res.

      Volume: 2 Issue: 2 Pages: 115-122

    • DOI

      10.1039/c2tx20050c

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ICP-AESとICP-MSの一般試験法への新規収載2012

    • Author(s)
      小椋康光
    • Journal Title

      ファームテックジャパン

      Volume: 28 Pages: 2791-2794

    • Related Report
      2013 Final Research Report
  • [Journal Article] Selenometabolomics explored by speciation2012

    • Author(s)
      Y. Ogra and Y. Anan
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 35 Pages: 1863-1869

    • NAID

      130001872280

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] スペシエーションを基盤としたメタロミクス研究の展開2012

    • Author(s)
      小椋康光
    • Journal Title

      分析化学

      Volume: 61 Pages: 513-522

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison in accumulation of lanthanide elements among three Brassicaceae plant sprouts2012

    • Author(s)
      Y. Anan, Y. Awaya, Y. Ogihara, M. Yoshida, A. Yawata and Y. Ogra
    • Journal Title

      Bull. Environ. Contam. Toxicol

      Volume: 89 Issue: 1 Pages: 133-137

    • DOI

      10.1007/s00128-012-0665-0

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Distribution and metabolism of selenite and selenomethionine in Japanese quail2012

    • Author(s)
      Y. Anan, A. Ohbo, Y. Tani, Y. Hatakeyama, A. Yawata and Y. Ogra
    • Journal Title

      Metallomics

      Volume: 4 Issue: 5 Pages: 457-462

    • DOI

      10.1039/c2mt20013a

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] Evaluation of arsenic (+3 oxidation state) methyltransferase activity to tellurite2014

    • Author(s)
      Maki Tokumoto, Natsuko Kutsukake, Erika Yamanishi, Yasumi Anan, Yasumitsu Ogra
    • Organizer
      The 53rd Annual Meeting of the Society of Toxicology
    • Place of Presentation
      Arizona, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] 鳥類における無機水銀の母卵間移行と亜セレン酸の抑制効果2014

    • Author(s)
      阿南弥寿美、谷祐太、海藤智仁、加藤祐、小椋康光
    • Organizer
      日本薬学会第134回年会
    • Place of Presentation
      熊本
    • Related Report
      2013 Final Research Report
  • [Presentation] Evaluation of arsenic (+3 oxidation state) methyltransferase activity to tellurite.2014

    • Author(s)
      Tokumoto M
    • Organizer
      The 53rd Annual Meeting of the Society of Toxicology
    • Place of Presentation
      Phoenix Convention Center (Phoenix, AZ, USA)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Alternative metabolic pathway of selenium in mammalian cell lines2013

    • Author(s)
      Yasumitsu Ogra
    • Organizer
      The 1^<st> Franco-Japanese Workshop on Metallomics
    • Place of Presentation
      Pau, France
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Speciation and imaging of bio trace elements2013

    • Author(s)
      Yasumitsu Ogra
    • Organizer
      The 86th Annual Meeting of the Japanese Biochemical Society
    • Place of Presentation
      Yokohama, Japan (International symposium)
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Identification of novel tellurium metabolites in selenium-accumulating plants2013

    • Author(s)
      Yasumitsu Ogra
    • Organizer
      Xth International Society for Trace Element Research in Humans
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] セレン蓄積性植物Allium sativumにおけるテルル代謝物の解析2013

    • Author(s)
      吉田美雪、小椋康光
    • Organizer
      日本薬学会第133回年会
    • Place of Presentation
      横浜(依頼講演)
    • Related Report
      2013 Final Research Report
  • [Presentation] Allium sativumによる類金属吸収能力の比較2013

    • Author(s)
      粟屋佑美、阿南弥寿美、德本真紀、小椋康光
    • Organizer
      日本薬学会第133回年会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] 血清中セレンタンパク質のげっ歯類における種差の解析2013

    • Author(s)
      畠山佳子、德本真紀、阿南弥寿美、小椋康光
    • Organizer
      日本薬学会第133回年会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] ラット副腎髄質由来褐色細胞PC12の神経細胞分化における銅の作用の解明2013

    • Author(s)
      手島彩、德本真紀、石塚雄大、阿南弥寿美、小椋康光
    • Organizer
      第23回金属の関与する生体関連反応シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 培養細胞内における新規セレン代謝物の生成とその機能2013

    • Author(s)
      小椋康光、木村桃子、德本真紀、阿南弥寿美
    • Organizer
      第24回日本微量元素学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2013 Final Research Report
  • [Presentation] セレン蓄積性植物におけるテルル代謝物の同定2013

    • Author(s)
      阿南弥寿美、吉田美雪、長谷川早喜、德本真紀、小椋康光
    • Organizer
      40回日本毒性学会学術年会
    • Place of Presentation
      千葉
    • Related Report
      2013 Final Research Report
  • [Presentation] 亜セレン酸を曝露したHepG2細胞における新規セレン代謝物の同定2013

    • Author(s)
      阿南弥寿美、林真理奈、木村桃子、德本真紀、小椋康光
    • Organizer
      第40回日本毒性学会学術年会
    • Place of Presentation
      千葉
    • Related Report
      2013 Final Research Report
  • [Presentation] Identification of tellurium metabolite in the selenium accumulator plant, garlic exposed with tellurate2013

    • Author(s)
      Yasumi Anan, Miyuki Yoshida, Saki Hasegawa, Ryota Katai, Maki Tokumoto, Laurent Ouerdane, RyszardŁobiński, Yasumitsu Ogra
    • Organizer
      4th International Symposium on Metallomics
    • Place of Presentation
      Oviedo, Spain
    • Related Report
      2013 Final Research Report
  • [Presentation] Evaluation of recombinant human arsenic (+3 oxidative state) methyltransferase for the methylation of tellurite in vitro2013

    • Author(s)
      Maki Tokumoto, Natsuko Kutsukake, Yasumi Anan, Yasumitsu Ogra
    • Organizer
      4th International Symposium on Metallomics
    • Place of Presentation
      Oviedo, Spain
    • Related Report
      2013 Final Research Report
  • [Presentation] Changes in the copper concentration and the expression of copper-regulating genes during the differentiation of pheochromocytoma, PC12, to neural cells2013

    • Author(s)
      Aya Tejima, Maki Tokumoto, Yudai Ishizuka, Yasumi Anan, Yasumitsu Ogra
    • Organizer
      4th International Symposium on Metallomics
    • Place of Presentation
      Oviedo, Spain
    • Related Report
      2013 Final Research Report
  • [Presentation] Effect of selenium on transfer of mercury to eggs in Japanese quails2013

    • Author(s)
      Yuta Tani, Tomohito Kaito, Yasumi Anan, Yasumitsu Ogra
    • Organizer
      4th International Symposium on Metallomics
    • Place of Presentation
      Oviedo, Spain
    • Related Report
      2013 Final Research Report
  • [Presentation] Identification of selenium metabolite in cultured cells and elucidation of its biological roles2013

    • Author(s)
      Momoko Kimura, Yasumi Anan, Marina Hayashi, Maki Tokumoto, Yasumitsu Ogra
    • Organizer
      4th International Symposium on Metallomics
    • Place of Presentation
      Oviedo, Spain
    • Related Report
      2013 Final Research Report
  • [Presentation] 亜セレン酸を摂取した産卵期ニホンウズラにおける水銀体内分布2013

    • Author(s)
      谷祐太、阿南弥寿美、海藤智仁、小椋康光
    • Organizer
      第22回環境化学討論会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] セレン蓄積性植物における無機テルル代謝機構の解明2013

    • Author(s)
      吉田美雪、阿南弥寿美、長谷川早喜、德本真紀、小椋康光
    • Organizer
      第22回環境化学討論会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] セレン蓄積性植物における有機セレン化合物の蓄積及び代謝機構の解析2013

    • Author(s)
      荻原友里絵、德本真紀、阿南弥寿美、小椋康光
    • Organizer
      第22回環境化学討論会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 亜セレン酸を摂取したウズラにおける卵へ水銀移行と分布にセレンが及ぼす影響2013

    • Author(s)
      海藤智仁、谷祐太、阿南弥寿美、小椋康光
    • Organizer
      第22回環境化学討論会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 培養細胞で検出されるセレン代謝物の同定およびその生体内挙動の解析2013

    • Author(s)
      阿南弥寿美、木村桃子、長谷川早喜、德本真紀、小椋康光
    • Organizer
      フォーラム2013衛生薬学・環境トキシコロジー
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
  • [Presentation] 神経細胞分化における銅の蓄積変化2013

    • Author(s)
      德本真紀、手島彩、畠山直大、阿南弥寿美、小椋康光
    • Organizer
      フォーラム2013衛生薬学・環境トキシコロジー
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
  • [Presentation] 組換え3価ヒ素メチル化酵素の類金属に対する活性評価2013

    • Author(s)
      沓掛夏子、德本真紀、阿南弥寿美、小椋康光
    • Organizer
      フォーラム2013衛生薬学・環境トキシコロジー
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
  • [Presentation] 類金属曝露が3価ヒ素メチル化酵素に与える影響2013

    • Author(s)
      山西絵利加、德本真紀、阿南弥寿美、小椋康光
    • Organizer
      フォーラム2013衛生薬学・環境トキシコロジー
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
  • [Presentation] Identification of selenium metabolite in cultured cells and elucidation of its biological role2013

    • Author(s)
      Yasumitsu Ogra, Momoko Kimura, Saki Hasegawa, Maki Tokumoto, Yasumi Anan
    • Organizer
      10th International Symposium on Selenium in Biology and Medicine
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2013 Final Research Report
  • [Presentation] Distribution and maternal transfer of mercury in Japanese quails ingesting sodium selenite2013

    • Author(s)
      Yasumi Anan, Yuta Tani, Tomohito Kaito, Yasumitsu Ogra
    • Organizer
      10th International Symposium on Selenium in Biology and Medicine
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2013 Final Research Report
  • [Presentation] 重金属依存性転写活性化におけるメタロチオネインの影響2013

    • Author(s)
      德本真紀、原友里、八幡紋子、鈴木薫、小泉信滋、小椋康光
    • Organizer
      メタルバイオサイエンス研究会2013
    • Place of Presentation
      静岡
    • Related Report
      2013 Final Research Report
  • [Presentation] 類金属代謝における3価ヒ素メチル化酵素の役割2013

    • Author(s)
      德本真紀、山西絵利加、小椋康光
    • Organizer
      メタルバイオサイエンス研究会2013
    • Place of Presentation
      静岡
    • Related Report
      2013 Final Research Report
  • [Presentation] PC12細胞の神経分化による銅に対する感受性の変化2013

    • Author(s)
      畠山直大、德本真紀、手島彩、阿南弥寿美、小椋康光
    • Organizer
      メタルバイオサイエンス研究会2013
    • Place of Presentation
      静岡
    • Related Report
      2013 Final Research Report
  • [Presentation] ラットにおける新規セレン代謝物セレノシアネートの生体内挙動の解析2013

    • Author(s)
      長谷川早喜、德本真紀、阿南弥寿美、小椋康光
    • Organizer
      第57回日本薬学会関東支部大会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] スペシエーションを用いた細胞内銅制御機構の解明2013

    • Author(s)
      小椋康光
    • Organizer
      第23回日本微量元素学会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Alternative metabolic pathway of selenium in mammalian cell lines.2013

    • Author(s)
      Ogra Y
    • Organizer
      The 1st Franco-Japanese Workshop on Metallomics
    • Place of Presentation
      Universite de Pau et des Pays de l'Adour (Pau, France)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Identification of novel tellurium metabolites in selenium-accumulating plants.2013

    • Author(s)
      Ogra Y
    • Organizer
      Xth International Society for Trace Element Research in Humans
    • Place of Presentation
      Keio Plaza Hotel (Tokyo, Japan)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Identification of selenium metabolite in cultured cells and elucidation of its biological role.2013

    • Author(s)
      Ogra Y
    • Organizer
      10th International Symposium on Selenium in Biology and Medicine
    • Place of Presentation
      Seminaris Campus Hotel (Berlin, Germany)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Identification of selenium metabolite in cultured cells and elucidation of its biological roles.2013

    • Author(s)
      Kimura M
    • Organizer
      4th International Symposium on Metallomics
    • Place of Presentation
      Calatrava Congress Center (Oviedo Spain)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Speciation of selenium- and tellurium-metabolites in animals and plants2012

    • Author(s)
      Yasumitsu Ogra
    • Organizer
      The 2nd Korea-China Joint Seminar on Selenium in Nutrition, Biochemistry and Cancer
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Recent advances in speciation of metal/metalloid metabolites2012

    • Author(s)
      Yasumitsu Ogra
    • Organizer
      2012 Singapore/Japan Joint Meeting on Biometals
    • Place of Presentation
      Singapore
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] テルル含有アミノ酸の合成とその生物活性評価2012

    • Author(s)
      片井涼太、阿南弥寿美、德本真紀、小椋康光
    • Organizer
      第22回金属の関与する生体関連反応シンポジウム
    • Place of Presentation
      金沢
    • Related Report
      2013 Final Research Report
  • [Presentation] Speciation of serum selenoproteins in mammals by HPLC-ICP-MS2012

    • Author(s)
      Yasumi Anan, Yoshiko Hatakeyama, Maki Tokumoto, Yasumitsu Ogra
    • Organizer
      7th International Franco-Spanish Workshop on Bio-Inorganic Analytical Chemistry
    • Place of Presentation
      Gijón, Spain
    • Related Report
      2013 Final Research Report
  • [Presentation] セレン化合物を投与したウズラにおけるセレンの化学形態分析2012

    • Author(s)
      大保愛、谷祐太、阿南弥寿美、小椋康光
    • Organizer
      21回環境化学討論会
    • Place of Presentation
      松山
    • Related Report
      2013 Final Research Report
  • [Presentation] セレン化合物を投与したウズラにおけるセレンの体内分布と排泄2012

    • Author(s)
      谷祐太、大保愛、阿南弥寿美、小椋康光
    • Organizer
      第21回環境化学討論会
    • Place of Presentation
      松山
    • Related Report
      2013 Final Research Report
  • [Presentation] ウズラにおける無機および有機セレン化合物の蓄積と代謝物の解析2012

    • Author(s)
      阿南弥寿美、大保愛、谷祐太、畠山佳子、八幡紋子、小椋康光
    • Organizer
      第39回日本毒性学会学術年会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] アブラナ科植物における有機セレン化合物の代謝機構の解明2012

    • Author(s)
      片山文音、荻原友里絵、八幡紋子、阿南弥寿美、小椋康光
    • Organizer
      第39回日本毒性学会学術年会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] Distribution and metabolism of inorganic- and organic selenocompounds in Japanese quail2012

    • Author(s)
      Yasumi Anan, Ai Ohbo, Yuta Tani, Yoshiko Hatakeyama, Ayako Yawata, Yasumitsu Ogra
    • Organizer
      The 6th International Congress of Asian Society of Toxicology
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] Metabolism of organic selenometabolites in brassicaceae family plants2012

    • Author(s)
      Ayane Katayama, Yurie Ogihara, Ayako Yawata, Yasumi Anan, Yasumitsu Ogra
    • Organizer
      The 6th International Congress of Asian Society of Toxicology
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] 化学形態分析による鳥類特異的なセレン代謝経路の解析2012

    • Author(s)
      大保愛、谷祐太、阿南弥寿美、小椋康光
    • Organizer
      第3回メタロミクス研究フォーラム
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] ニホンウズラにおけるセレンの体内分布及び排泄の経時変化2012

    • Author(s)
      谷祐太、大保愛、阿南弥寿美、小椋康光
    • Organizer
      第3回メタロミクス研究フォーラム
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] HepG2細胞における亜セレン酸曝露後のセレンのスペシエーション2012

    • Author(s)
      林真理奈、木村桃子、杉山尚樹,德本真紀、阿南弥寿美、小椋康光
    • Organizer
      第3回メタロミクス研究フォーラム
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] セレン蓄積性植物における有機セレン化合物の代謝機構の解明2012

    • Author(s)
      片山文音、荻原友里絵、德本真紀、阿南弥寿美、小椋康光
    • Organizer
      第3回メタロミクス研究フォーラム
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 亜テルル酸を曝露したニンニクにおけるテルル代謝物の解析2012

    • Author(s)
      吉田美雪、長谷川早喜、阿南弥寿美、小椋康光
    • Organizer
      第3回メタロミクス研究フォーラム
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] HepG2細胞における新規セレン代謝物の各種質量分析法によるスペシエーション2012

    • Author(s)
      林真理奈、木村桃子、杉山尚樹、德本真紀、阿南弥寿美、小椋康光
    • Organizer
      日本分析化学会第61年会
    • Place of Presentation
      金沢
    • Related Report
      2013 Final Research Report
  • [Presentation] ウズラ卵における必須および毒性元素の分布と化学形態分析2012

    • Author(s)
      阿南弥寿美、谷祐太、海藤智仁、徳本真紀、小椋康光
    • Organizer
      日本分析化学会第61年会
    • Place of Presentation
      金沢
    • Related Report
      2013 Final Research Report
  • [Presentation] 齧歯類における血清中セレンタンパク質の解析2012

    • Author(s)
      阿南弥寿美、畠山佳子、德本真紀、小椋康光
    • Organizer
      フォーラム2012衛生薬学・環境トキシコロジー
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
  • [Book] 化学形態別分析、毒性の科学(熊谷嘉人、姫野誠一郎、渡邊知保編)2014

    • Author(s)
      小椋康光(分担執筆)
    • Publisher
      東京大学出版会、東京
    • Related Report
      2013 Final Research Report
  • [Book] 毒性の科学2014

    • Author(s)
      小椋康光
    • Total Pages
      200
    • Publisher
      東京大学出版
    • Related Report
      2013 Annual Research Report
  • [Book] 生物学辞典第5版(厳佐庸、倉谷滋、斎藤成也、塚谷雄一編)2013

    • Author(s)
      小椋康光(分担執筆)
    • Publisher
      岩波書店、東京
    • Related Report
      2013 Final Research Report
  • [Book] 食品中の微量元素(米谷民雄編)2013

    • Author(s)
      小椋康光(分担執筆)
    • Publisher
      日本食品衛生協会、東京
    • Related Report
      2013 Final Research Report
  • [Book] 生物学辞典第5版2013

    • Author(s)
      小椋康光
    • Total Pages
      2171
    • Publisher
      岩波書店
    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.shoyaku.ac.jp/labosite/eisei/index.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 所属研究室

    • URL

      http://www.shoyaku.ac.jp/laboratory/eisei.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 現在のプロジェクト

    • URL

      http://www.covalent.hrc.shoyaku.ac.jp/

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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