| Project/Area Number |
24659031
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
KATOH Hironori 京都大学, 生命科学研究科, 准教授 (50303847)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAUCHI Junji 独立行政法人国立成育医療研究センター, 室長 (20335483)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 細胞・組織 / シグナル伝達 / 脳・神経 / 発生 |
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| Research Abstract |
In the developing cerebral cortex, the regulation of neural progenitor cell proliferation is one of most important element for the determination of the total number of neurons and the formation of the functional cerebral cortex. In this research, we focused on the regulatory factors for the activities of Rho family G proteins, which function as molecular switches of signal transductions. We analyzed expression periods and patterns of regulatory factors during the development of the cerebral cortex, and obtained results indicating the possibility that srGAP3 is involved in the migration of neurons in the cerebral cortex during early developmental stages.
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