Elucidation of the molecular mechanisms of immunological tolerance in liver

Research Project

Project/Area Number	24659032
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Single-year Grants
Research Field	Biological pharmacy
Research Institution	Osaka University
Principal Investigator	TACHIBANA Masashi 大阪大学, 薬学研究科(研究院), 助教 (80513449)
Project Period (FY)	2012-04-01 – 2014-03-31
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	免疫学 / 免疫寛容 / 肝臓 / 免疫寛容・抑制 / T細胞
Research Abstract	Liver exhibits the feature of immunological tolerance. Although several mechanisms have been suggested, it still remain unclear. In this study, we found that an immunosuppressive cytokine expression was higher in liver than in spleen of naïve mice. Moreover, we found that liver sinusoidal endothelial cells, which exist only in liver, enhanced an immunosuppressive cytokine expression by the stimulation of other cytokine. These findings would lead to the understanding of immunological tolerance and the therapy for several liver diseases.