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Elucidation of the molecular mechanisms of immunological tolerance in liver

Research Project

Project/Area Number 24659032
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionOsaka University

Principal Investigator

TACHIBANA Masashi  大阪大学, 薬学研究科(研究院), 助教 (80513449)

Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords免疫学 / 免疫寛容 / 肝臓 / 免疫寛容・抑制 / T細胞
Research Abstract

Liver exhibits the feature of immunological tolerance. Although several mechanisms have been suggested, it still remain unclear. In this study, we found that an immunosuppressive cytokine expression was higher in liver than in spleen of naïve mice. Moreover, we found that liver sinusoidal endothelial cells, which exist only in liver, enhanced an immunosuppressive cytokine expression by the stimulation of other cytokine. These findings would lead to the understanding of immunological tolerance and the therapy for several liver diseases.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (2 results)

All Other

All Remarks (2 results)

  • [Remarks] 大阪大学大学院薬学研究科分子生物学分野

    • URL

      https://sites.google.com/site/bunshiseibutugaku/

    • Related Report
      2013 Final Research Report
  • [Remarks] 大阪大学大学院薬学研究科分子生物学分野

    • URL

      https://sites.google.com/site/bunshiseibutugaku/

    • Related Report
      2013 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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