Elucidation of the molecular mechanisms of immunological tolerance in liver

• Project/Area Number: 24659032
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Biological pharmacy
• Research Institution: Osaka University
• Principal Investigator: TACHIBANA Masashi 大阪大学, 薬学研究科(研究院), 助教 (80513449)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 免疫学 / 免疫寛容 / 肝臓 / 免疫寛容・抑制 / T細胞

Research Abstract

Liver exhibits the feature of immunological tolerance. Although several mechanisms have been suggested, it still remain unclear. In this study, we found that an immunosuppressive cytokine expression was higher in liver than in spleen of naïve mice. Moreover, we found that liver sinusoidal endothelial cells, which exist only in liver, enhanced an immunosuppressive cytokine expression by the stimulation of other cytokine. These findings would lead to the understanding of immunological tolerance and the therapy for several liver diseases.

Research Products

• [Remarks] 大阪大学大学院薬学研究科分子生物学分野
  • URL: https://sites.google.com/site/bunshiseibutugaku/
• [Remarks] 大阪大学大学院薬学研究科分子生物学分野
  • URL: https://sites.google.com/site/bunshiseibutugaku/