Can augmentation of Reelin function be a novel therapy against neuropsychiatric diseases?
| Project/Area Number |
24659036
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Nagoya City University |
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Principal Investigator |
HATTORI Mitsuharu 名古屋市立大学, 薬学研究科(研究院), 教授 (60272481)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | リーリン / 脳 / アルツハイマー病 / 神経発生 / プロテオリシス / プロテアーゼ / タンパク質 |
|---|
| Research Abstract |
Reelin plays important roles in the brain functions. Reelin is inactivated by a specify proteolysis but the enzyme in charge of this reaction remained elusive. In this study we found that Reelin is specifically cleaved by a member of ADAMTS metalloproteinase family. We also established an uncleavable mutant of Reelin. These informations and tools will be helpful for future therapy of neuropsychiatric diseases.
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Report
(3 results)
Research Products
(66 results)
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[Journal Article] Cleavage Within Reelin Repeat 3 Regulates the Duration and Range of Signaling Activity of Reelin2014
Author(s)
Koie, M., Okumura, K., Hisanaga, A., Kamei, T., Sasaki, K., Deng, M., Baba, A., Kohno, T., and Hattori, M.
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Journal Title
J. Biol. Chem.
Volume: 289
Pages: 12922-12930
Related Report
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[Journal Article] Dab1-mediated colocalization of multi-adaptor protein CIN85 with Reelin receptors, ApoER2 and VLDLR, in neurons2013
Author(s)
Fuchigami, T., Sato, Y., Tomita, Y., Takano, T., Miyauchi, S.Y., Tsuchiya, Y., Saito, T., Kubo, K., Nakajima, K., Fukuda, M., Hattori, M., and Hisanaga, S.
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Journal Title
Genes Cell
Volume: 18
Pages: 410-24
Related Report
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[Journal Article] Type 1 inositol trisphosphate receptor regulates cerebellar circuits by maintaining the spine morphology of purkinje cells in adult mice2013
Author(s)
Sugawara, T., Hisatsune, C., Le, T.D., Hashikawa, T,, Hirono, M., Hattori, M., Nagao, S., and Mikoshiba, K.
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Journal Title
J. Neurosci.
Volume: 33
Pages: 12186-96
Related Report
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[Journal Article] Exogenous Reelin Modifies the Migratory Behavior of Neurons Depending on Cortical Location2013
Author(s)
Britto, J.M., Tait, K.J., Lee, E.P., Gamble, R.S., Hattori, M., and Tan, S.S.
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Journal Title
Cereb. Cortex
Volume: (in press)
Related Report
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[Journal Article] IP3R1 deficiency in the cerebellum/brainstem causes basal ganglia-independent dystonia by triggering tonic Purkinje cell firings in mice2013
Author(s)
Hisatsune, C., Miyamoto, H., Hirono, M., Yamaguchi, N., Sugawara, T., Ogawa, N., Ebisui, E., Ohshima, T., Yamada, M., Hensch, T.K., Hattori, M., and Mikoshiba, K.
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Journal Title
Front. Neural Circuits
Volume: 7
Pages: 156-156
Related Report
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[Journal Article] Dab1-mediated colocalization of multi-adaptor protein CIN85 with Reelin-receptors, ApoER2 or VLDLR, in neurons.2013
Author(s)
T.Fuchigami, Y.Sato1, Y.Tomita1, T.Takano, S.Miyauchi, Y.Tsuchiya, T.Saito, K.Kubo, K.Nakajima, M.Fukuda, M.Hattori, and S.Hisanaga
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Journal Title
Genes to Cells
Volume: in press
Issue: 5
Pages: 410-424
DOI
Related Report
Peer Reviewed
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[Journal Article] A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) cleaves Reelin in an isoform-dependent manner2012
Author(s)
Hisanaga, A., Morishita, S., Suzuki, K., Sasaki, K., Koie, M., Kohno, T., and Hattori, M.
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Journal Title
FEBS Lett
Volume: 586
Pages: 3349-3353
Related Report
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[Journal Article] Reelin controls neuronal migration and positioning by promoting neuronal adhesion to extracellular matrix via the inside-out activation of integrinα5β12012
Author(s)
Sekine, K., Kawauchi, T., Kubo, K., Honda, T., Herz, J., Hattori, M., Kinashi, T., and Nakajima, K.
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Journal Title
Neuron
Volume: 76
Pages: 353-369
Related Report
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[Journal Article] LPIAT1 regulates arachidonic acid content in phosphatidylinositol and is required for cortical lamination in mice2012
Author(s)
Lee, H.C., Inoue, T., Sasaki, J., Kubo, T., Matsuda, S., Nakasaki, Y., Hattori, M., Tanaka, F., Udagawa, O., Kono, N., Itoh, T., Ogiso, H., Taguchi, R., Arita, M., Sasaki, T., and Arai, H.
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Journal Title
Mol. Biol. Cell
Volume: 23
Pages: 4689-700
Related Report
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[Journal Article] Reelin-dependent ApoER2 downregulation uncouples newborn neurons from progenitor cells
Author(s)
Perez-Martinez, F. J., Luque-Rio, A,, Sakakibara, A., Hattori, M., Miyata, T., and Luque, J. M.
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Journal Title
Biol. Open
Volume: 1
Pages: 1258-1263
Related Report
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