Synthesis of PEGylated drug candidates for PET imaging
Project/Area Number |
24659049
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Drug development chemistry
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Research Institution | Osaka University (2013-2014) University of Shizuoka (2012) |
Principal Investigator |
AKAI Shuji 大阪大学, 薬学研究科(研究院), 教授 (60192457)
|
Co-Investigator(Renkei-kenkyūsha) |
OKU Naoto 静岡県立大学, 薬学部, 教授 (10167322)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | ポリエチレングリコール / クリック化学 / ペプチド / PEG化医薬品 / イメージング / 創薬 / フッ素アニオン / 蛍光色素 / PEG / Huisgen反応 / フッ素化 / 体内動態解析 / PEG化医薬品 / フルオラス化学 |
Outline of Final Research Achievements |
The covalent attachment of poly(ethylene glycol) (PEG) with an average molecular weight (Mw) of 5-40 kDa to a drug or a therapeutic protein, called PEGylation, is a common strategy to evade the host immune system, to enhance its stability in blood, etc. In this study, we have developed a synthetic method of PEGylated peptides, possessing a fluorescent moiety at one end of the PEG chain, which enabled noninvasive whole-body trafficking of such molecules in living rats.
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Report
(4 results)
Research Products
(5 results)
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[Journal Article] Real-time trafficking of PEGylated liposomes in the rodent focal brain ischemia analyzed by positron emission tomography2014
Author(s)
Fukuta T, Ishii T, Asai T, Nakamura G, Takeuchi Y, Sato A, Agato Y, Shimizu K, Asai S, Fukumoto D, Harada N, Tsukada H, Kawaguchi AT, Oku N
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Journal Title
Artificial organs
Volume: 38
Issue: 8
Pages: 662-6
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Dynamic Analysis of Fluid Distribution in the Gastrointestinal Tract in Rats: Positron Emission Tomography Imaging after Oral Administration of Nonabsorbable Marker, [(18)F]Deoxyfluoropoly(ethylene glycol)2013
Author(s)
Takashima T, Shingaki T, Katayama Y, Hayashinaka E, Wada Y, Kataoka M, Ozaki D, Doi H, Suzuki M, Ishida S, Hatanaka K, Sugiyama Y, Akai S, Oku N, Yamashita S, Watanabe Y
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Journal Title
Mol. Pharmaceutics
Volume: 10
Issue: 6
Pages: 2261-2269
DOI
Related Report
Peer Reviewed
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