| Project/Area Number |
24659049
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | Osaka University (2013-2014)
University of Shizuoka (2012) |
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Principal Investigator |
AKAI Shuji 大阪大学, 薬学研究科(研究院), 教授 (60192457)
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| Co-Investigator(Renkei-kenkyūsha) |
OKU Naoto 静岡県立大学, 薬学部, 教授 (10167322)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ポリエチレングリコール / クリック化学 / ペプチド / ＰＥＧ化医薬品 / イメージング / 創薬 / フッ素アニオン / 蛍光色素 / PEG / Huisgen反応 / フッ素化 / 体内動態解析 / PEG化医薬品 / フルオラス化学 |
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| Outline of Final Research Achievements |
The covalent attachment of poly(ethylene glycol) (PEG) with an average molecular weight (Mw) of 5-40 kDa to a drug or a therapeutic protein, called PEGylation, is a common strategy to evade the host immune system, to enhance its stability in blood, etc. In this study, we have developed a synthetic method of PEGylated peptides, possessing a fluorescent moiety at one end of the PEG chain, which enabled noninvasive whole-body trafficking of such molecules in living rats.
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