| Project/Area Number |
24659051
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | Waseda University |
|---|
Principal Investigator |
KOIDE Takaki 早稲田大学, 理工学術院, 教授 (70322253)
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|---|
| Co-Investigator(Renkei-kenkyūsha) |
UTANI Atsushi 長崎大学, 医学部, 教授 (10292707)
YASUI Hiroyuki 京都薬科大学, 薬学部, 教授 (20278443)
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|---|
| Project Period (FY) |
2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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|---|
| Keywords | コラーゲン / 線維化 / シスプラチン |
|---|
| Research Abstract |
Molecular mechanism for the inhibitory action of a cisplatin-DMSO complex on the collagen-fibril formation was investigated in vitro. The cisplatin complex was strongly suggested to target His and/or Met residues on the collagen triple helices. The complex was also shown to effectively inhibit the collagen fibril-formation and deposition in a human cell culture system.
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