| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The organic-inorganic hybrid molecules have been widely used in the field of organoelement chemistry. However, very little is known about the toxicity of the molecules. To investigate the vascular toxicity of nucleophilic organometallic compounds, vascular endothelial cell were cultured and treated with diphenylditelluride, diphenyldiselenide, a model compound, in the present study. Cytotoxicity and intracellular accumulation were determined and the effects of an electron-donating group (CH3O-) and an electron-withdrawing group (-Cl) on the cytotoxicity of DPDTe were evaluated. The data obtained suggest that the endothelial cytotoxicity of nucleophilic organometallic compounds depends on the intramolecular metal and electronic structure in the compounds.
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