Molecular targets and biological systems involved in the toxicity of nucleophilic organometallic compounds
| Project/Area Number |
24659058
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental pharmacy
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ハイブリッド分子 / 有機金属化合物 / 細胞毒性 / 有機テルル化合物 / 毒性 / バイオオルガノメタリクス / 金属毒性学 / 分子標的 / 有害化学物質 |
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| Outline of Final Research Achievements |
The organic-inorganic hybrid molecules have been widely used in the field of organoelement chemistry. However, very little is known about the toxicity of the molecules. To investigate the vascular toxicity of nucleophilic organometallic compounds, vascular endothelial cell were cultured and treated with diphenylditelluride, diphenyldiselenide, a model compound, in the present study. Cytotoxicity and intracellular accumulation were determined and the effects of an electron-donating group (CH3O-) and an electron-withdrawing group (-Cl) on the cytotoxicity of DPDTe were evaluated. The data obtained suggest that the endothelial cytotoxicity of nucleophilic organometallic compounds depends on the intramolecular metal and electronic structure in the compounds.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] The cytotoxicity of organobismuth compounds with certain molecular structures can be diminished by replacing the bismuth atom with an antimony atom in the molecules2015
Author(s)
Kohri, K., Yoshida, E., Yasuike, S., Fujie, T., Yamamoto, C., Kaji, T.
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Journal Title
Journal of Toxicological Sciences
Volume: 3
Pages: 321-327
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Comparative cytotoxicity of triphenylstibane and fluorine-substituted triarylpnictogens in cultured vascular endothelial cells2015
Author(s)
Murakami, M., Fujie, T., Matsumura, M., Yoshida, E., Yamamoto, C., Fujiwara, Y., Yasuike, S., Kaji
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Journal Title
Fundamental Toxicological Sciences
Volume: 2
Pages: 61-66
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] In vitro reversal of deformity and inhibition of aggregation of scikle red blood cells by two Congolese herbal medicines2012
Author(s)
Nsimba, M.M., Lami, J.M., Yamamoto, C., Kaji, T., Mukengeshaie, M., and Lufuluabo, M.
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Journal Title
Journal of Medical Plants Research
Volume: 6
Pages: 4801-4808
Related Report
Peer Reviewed
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