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Quantitative targeted absolute proteomics-based diagnostics for personalized cancer chemotherapy

Research Project

Project/Area Number 24659063
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Medical pharmacy
Research InstitutionTohoku University

Principal Investigator

TERASAKI TETSUYA  東北大学, 薬学研究科(研究院), 教授 (60155463)

Co-Investigator(Kenkyū-buntansha) UCHIDA Yasuo  東北大学, 大学院薬学研究科, 助教 (70583590)
NAKADA Mitsutoshi  金沢大学, 医学系, 助教 (20334774)
TACHIKAWA Masanori  東北大学, 大学院薬学研究科, 准教授 (00401810)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords分子標的薬 / 定量プロテオミクス / リン酸化 / 増殖因子受容体 / 個別化医療 / がん / 標的絶対定量プロテオミクス / 個別化 / 脳腫瘍 / 受容体
Research Abstract

There has been increasing demands for molecular-targeted drugs-based personalized cancer chemotherapy. Our findings provide the basis that the characteristics of human malignant brain tumors can be stratified according to the absolute protein expression levels of target receptors. Simultaneous and highly sensitive quantitative targeted phospho-proteomics has also been established.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (28 results)

All 2014 2013 2012 Other

All Journal Article (6 results) (of which Peer Reviewed: 4 results) Presentation (21 results) (of which Invited: 4 results) Book (1 results)

  • [Journal Article] Identification of transporters associated with etoposide sensitivity of stomach cancer cell lines and methotrexate sensitivity of breast cancer cell lines by quantitative targeted absolute proteomics2013

    • Author(s)
      Obuchi W, Ohtsuki S, Uchida Y, Ohmine K, Yamori T, Terasaki T
    • Journal Title

      Mol Pharmacol

      Volume: 83(2) Pages: 490-500

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative Expression of Human Drug Transporter Proteins in Lung Tissues : Analysis of Regional, Gender and Inter-individual differences by Liquid Chromatography-Tandem Mass Spectrometry. E-pub ahead of print2013

    • Author(s)
      Sakamoto A, Matsumaru T, Yamamura N, Uchida Y, Tachikawa M, Ohtsuki S, Terasaki T
    • Journal Title

      J Pharm Sci

      Volume: 102(9) Pages: 3395-3406

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Study Protocol for Quantitative Targeted Absolute Proteomics (QTAP) by LC-MS/MS : Application for Inter-Strain Differences in Protein Expression Levels of Transporters, Receptors, Claudin-5, and Marker Proteins at the Blood-Brain Barrier in ddY, FVB, and C57BL/6J mice2013

    • Author(s)
      Uchida Y, Tachikawa M, Obuchi W, Hoshi Y, Tomioka Y, Ohtsuki S, Terasaki T
    • Journal Title

      Fluids and Barriers of the CNS

      Volume: 10(1) Pages: 21-21

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 定量的標的プロテオミクスに基づく胃癌・乳癌薬剤感受性関連トランスポーターの解明2013

    • Author(s)
      小渕航、寺崎哲也
    • Journal Title

      医学のあゆみ

      Volume: 245(1) Pages: 135-141

    • Related Report
      2013 Final Research Report
  • [Journal Article] Identification of transporters associated with Etoposide sensitivity of stomach cancer cell lines and methotrexate sensitivity of breast cancer cell lines by quantitative targeted absolute proteomics2013

    • Author(s)
      Obuchi W, Ohtsuki S, Uchida Y, Ohmine K, Yamori T, Terasaki T
    • Journal Title

      Mol Pharmacol

      Volume: 83(2) Issue: 2 Pages: 490-500

    • DOI

      10.1124/mol.112.081083

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 定量的標的プロテオミクスに基づく胃癌・乳癌薬剤感受性関連トランスポーターの解明2013

    • Author(s)
      小渕航
    • Journal Title

      医学のあゆみ

      Volume: 245 Pages: 135-141

    • Related Report
      2012 Research-status Report
  • [Presentation] 標的絶対定量プロテオミクスに基づくがん分子標的化学療法の個別・層別化基盤の構築2014

    • Author(s)
      内田康雄、立川正憲、小渕航、大槻純男、中田光俊、濱田潤一郎、寺崎哲也
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Year and Date
      2014-03-29
    • Related Report
      2013 Final Research Report
  • [Presentation] 血液脳関門—白血球細胞遊走に関わる接着分子の標的定量プロテオミクス解析2014

    • Author(s)
      佐藤和貴、立川正憲、内田康雄、大槻純男、寺崎哲也
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Year and Date
      2014-03-29
    • Related Report
      2013 Final Research Report
  • [Presentation] 前処理自動化と質量分析を組み合わせたハイスループットMRM法の開発2014

    • Author(s)
      米山敏広、大槻純男、尾野雅哉、大峰健、内田康雄、立川正憲、寺崎哲也
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Year and Date
      2014-03-29
    • Related Report
      2013 Final Research Report
  • [Presentation] 定量的標的絶対プロテオミクスに基づく癌化学療法の新展開2013

    • Author(s)
      寺崎哲也
    • Organizer
      公益社団法人・日本薬剤学会主催APSTJ WG 2025シンポジウム「バイオとナノが拓く医療イノベーション」
    • Place of Presentation
      東京
    • Year and Date
      2013-12-03
    • Related Report
      2013 Final Research Report
  • [Presentation] Quantitative targeted absolute proteomics of the malignant brain tumors towards molecular-targeted chemotherapy2013

    • Author(s)
      Terasaki T, Obuchi W, Ohtsuki S, Nakada M, Uchida Y, Tachikawa M, Hamada J
    • Organizer
      10th International Society for the Study of Xenobiotics (ISSX) Meeting
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2013-09-30
    • Related Report
      2013 Final Research Report
  • [Presentation] Pharmacoproteomics : 定量的標的絶対プロテオミクスに基づく薬剤学の新展開2013

    • Author(s)
      寺崎哲也
    • Organizer
      薬剤学教科担当教員会議
    • Place of Presentation
      富山
    • Year and Date
      2013-08-30
    • Related Report
      2013 Final Research Report
  • [Presentation] 膜タンパク質を標的とした定量的標的プロテオミクスに基づく悪性脳腫瘍に対する個別化分子標的療法2013

    • Author(s)
      小渕航、大槻純男、中田光俊、内田康雄、立川正憲、濱田潤一郎、寺崎哲也
    • Organizer
      日本薬剤学会第28年会
    • Place of Presentation
      名古屋
    • Year and Date
      2013-05-23
    • Related Report
      2013 Final Research Report
  • [Presentation] 膵癌細胞のゲムシタビン感受性増強を目的とした併用薬のスクリーニング2013

    • Author(s)
      黒田広樹、立川正憲、内田康雄、寺崎哲也
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 仮想selective reaction monitoring法を用いた白血球細胞膜上タンパク質の高感度標的プロテオミクス2013

    • Author(s)
      佐藤和貴、立川正憲、内田康雄、大槻純男、寺崎哲也
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-28
    • Related Report
      2013 Final Research Report
  • [Presentation] Pharmacoproteomics : Quantitative Targeted Absolute Proteomics (QTAP) based Pharmacokinetics as A New Path to the Drug Discovery and Development and the Personalized Medicine2013

    • Author(s)
      Terasaki T
    • Organizer
      International Symposium for the retirement of Professor Chang Koo Shim
    • Place of Presentation
      Seoul National University, Seoul, South Korea
    • Related Report
      2013 Final Research Report
  • [Presentation] Quantitative targeted absolute proteomics of the malignant brain tumors towards molecular-targeted chemotherapy.2013

    • Author(s)
      Terasaki T., Obuchi W., Ohtsuki S.,Nakada M., Uchida Y., Tachikawa M., Hamada J.
    • Organizer
      10th International ISSX Meeting
    • Place of Presentation
      Toronto, Canada
    • Related Report
      2013 Annual Research Report
  • [Presentation] Targeted quantitative LC-MS/MS methods of bevacizumab, a therapeutic monoclonal antibody2012

    • Author(s)
      Ebata Y, Ohtsuki S, Tachikawa M, Uchida Y, Terasaki T
    • Organizer
      日本薬物動態学会第27年会
    • Place of Presentation
      千葉
    • Year and Date
      2012-11-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Proteomics-based technology as a new path to toxicological evaluation2012

    • Author(s)
      Tachikawa M
    • Organizer
      2012 International Symposium on Green Toxicology & Technology : Prediction of Kidney Toxicity
    • Place of Presentation
      Seoul, South Korea
    • Year and Date
      2012-09-07
    • Related Report
      2013 Final Research Report
  • [Presentation] Pharmacoproteomics: 定量的標的絶対プロテオミクスに基づく薬剤学の新展開

    • Author(s)
      寺崎哲也
    • Organizer
      薬剤学教科担当教員会議
    • Place of Presentation
      富山市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 定量的標的絶対プロテオミクスに基づく癌化学療法の新展開

    • Author(s)
      寺崎哲也
    • Organizer
      APSTJ2025WGシンポジウム
    • Place of Presentation
      東京都千代田区
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 膜タンパク質を標的とした定量的標的プロテオミクスに基づく悪性脳腫瘍に対する個別化分子標的療法

    • Author(s)
      小渕航、大槻 純男、中田 光俊、内田 康雄、立川 正憲、濱田 潤一郎、寺崎 哲也
    • Organizer
      日本薬剤学会第28年会
    • Place of Presentation
      名古屋市
    • Related Report
      2013 Annual Research Report
  • [Presentation] 標的絶対定量プロテオミクスに基づくがん分子標的化学療法の個別・層別化基盤の構築

    • Author(s)
      内田康雄、立川正憲、小渕航、大槻純男、中田光俊、濱田潤一郎、寺崎哲也
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 膵癌細胞のゲムシタビン感受性増強を目的とした併用薬のスクリーニング

    • Author(s)
      黒田広樹
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 仮想selective reaction monitoring法を用いた白血球細胞膜上タンパク質の高感度標的プロテオミクス

    • Author(s)
      佐藤和貴
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] Proteomics-based technology as a new path to toxicological evaluation

    • Author(s)
      Tachikawa M
    • Organizer
      2012 International Symposium on Green Toxicology & Technology: Prediction of Kidney Toxicity
    • Place of Presentation
      Seoul, South Korea
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Targeted quantitative LC-MS/MS methods of bevacizumab, a therapeutic monoclonal antibody.

    • Author(s)
      Ebata Y
    • Organizer
      日本薬物動態学会第27年会
    • Place of Presentation
      千葉
    • Related Report
      2012 Research-status Report
  • [Book] Blood-brain barrier (BBB) pharmacoproteomics : a new research field opened up by quantitative targeted absolute proteomics (QTAP). Drug Delivery to the Brain–Physiological Concepts, Methodologies and Approaches, Hammarlund-Udenaes M, de Lange E, and Thorne R (Ed)2014

    • Author(s)
      Uchida Y, Tachikawa M, Ohtsuki S, Terasaki T
    • Publisher
      Springer, New York
    • Related Report
      2013 Final Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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