Quantitative targeted absolute proteomics-based diagnostics for personalized cancer chemotherapy
| Project/Area Number |
24659063
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
UCHIDA Yasuo 東北大学, 大学院薬学研究科, 助教 (70583590)
NAKADA Mitsutoshi 金沢大学, 医学系, 助教 (20334774)
TACHIKAWA Masanori 東北大学, 大学院薬学研究科, 准教授 (00401810)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 分子標的薬 / 定量プロテオミクス / リン酸化 / 増殖因子受容体 / 個別化医療 / がん / 標的絶対定量プロテオミクス / 個別化 / 脳腫瘍 / 受容体 |
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| Research Abstract |
There has been increasing demands for molecular-targeted drugs-based personalized cancer chemotherapy. Our findings provide the basis that the characteristics of human malignant brain tumors can be stratified according to the absolute protein expression levels of target receptors. Simultaneous and highly sensitive quantitative targeted phospho-proteomics has also been established.
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Report
(3 results)
Research Products
(28 results)
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[Journal Article] A Study Protocol for Quantitative Targeted Absolute Proteomics (QTAP) by LC-MS/MS : Application for Inter-Strain Differences in Protein Expression Levels of Transporters, Receptors, Claudin-5, and Marker Proteins at the Blood-Brain Barrier in ddY, FVB, and C57BL/6J mice2013
Author(s)
Uchida Y, Tachikawa M, Obuchi W, Hoshi Y, Tomioka Y, Ohtsuki S, Terasaki T
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Journal Title
Fluids and Barriers of the CNS
Volume: 10(1)
Pages: 21-21
Related Report
Peer Reviewed
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