| Project/Area Number |
24659066
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Gunma University |
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Principal Investigator |
YAMAMOTO Koujirou 群馬大学, 医学(系)研究科(研究院), 教授 (70174787)
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| Co-Investigator(Kenkyū-buntansha) |
HASHITA Tadahiro 群馬大学, 大学院医学系研究科, 助教 (20613384)
AOMORI Tohru 慶応義塾大学, 薬学部, 講師 (40620802)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 薬物濃度モニタリング / 高感度微量定量法 / 高感度定量法 / 超微量分析 / 薬物治療モニタリング / 血球移行 / 微量定量法 / ＴＤＭ |
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| Outline of Final Research Achievements |
The highly sensitive measurement method with very small amount of sample is essential for a noninvasive therapeutic drug monitoring. In addition, blood sample is not separated to plasma and blood cell in spot sampling, which is usually utilized for small amount blood sampling. Therefore, the evaluation of the distribution of drug to blood cell is necessary to understand the relationship of measured concentration with noninvasive sampling and conventional blood sampling. In this study, we established the highly sensitive quantitation method for darunavir, an anti HIV drug to determine the drug concentration in blood and blood cell. Large inter-individual variability was observed in blood cell / plasma concentration ratio of darunavir, which suggests the contribution of some drug transporter function.
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