| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
Recently, NPC1L1, which mediates the intestinal cholesterol absorption and is a molecular target of ezetimibe for dyslipidemia, is actively studied and several important physiological functions other than cholesterol transport have been revealed. The aim of this study was to prove the hypothesis that intestinal transporters such as NPC1L1 are important for virus entry. Since in vitro and in vivo models for the experiments of intestinal virus entry are arranged, key molecules for virus entry from the small intestine should be revealed in the near future.
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