| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
The purpose of this study is to identify the endogenous probes that are applicable to in vivo evaluation of drug transporter activities in humans. The endogenous probes, the plasma or urinary excretion of which were associated with the transporter activities, were investigated in the biological samples from the healthy subjects who had been enrolled in the drug interaction studies. We could demonstrate that thiamine is a probe renal organic cation transporter (MATE), that 6beta-hydroxycortisol is a probe for renal organic anion transporter (OAT3). Their renal clearances were significantly reduced by the administration of inhibitors, showing their usefulness in the evaluation of drug-drug interactions involving these transporters.
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