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Molecular mechanisms of prostaglandin elimination across brain barriers and its application to neural inflammatory diseases

Research Project

Project/Area Number 24659072
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Medical pharmacy
Research InstitutionUniversity of Toyama

Principal Investigator

HOSOYA Ken-ichi  富山大学, 大学院医学薬学研究部(薬学), 教授 (70301033)

Co-Investigator(Kenkyū-buntansha) KUBO Yoshiyuki  富山大学, 大学院医学薬学研究部(薬学), 准教授 (20377427)
Co-Investigator(Renkei-kenkyūsha) TACHIKAWA Masanori  東北大学, 大学院薬学研究科, 准教授 (00401810)
AKANUMA Shin-ichi  富山大学, 大学院医学薬学研究部(薬学), 助教 (30467089)
Project Period (FY) 2012-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywordsプロスタグランジン / 血液脳関門 / 脳内炎症 / プロスタグランジン合成酵素 / 血液脳脊髄液関門 / リポ多糖 / 神経伝達物質 / PGE2
Research Abstract

The expression and localization of mPGES-1 and L-PGDS proteins was examined by immunohistochemical analysis. L-PGDS were expressed in leptomeningeal cells. The signals derived from mPGES-1 were detected in leptomeningeal cells and astrocytes. In the inflammatory model of mice, this mPGES-1 signal was strongly detected in brain capillary endothelial cells, which forms the blood-brain barrier (BBB). In this model, the elimination of PGD2, which is involved in the progression of inflammatory responses, across the BBB was attenuated. From these results, the BBB plays a role in the regulation of the physiological function of prostaglandins in the brain.

Report

(3 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • Research Products

    (4 results)

All 2014 2012 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Remarks (1 results)

  • [Journal Article] Distribution of microsomal prostaglandin E synthase-1 in the mouse brain2014

    • Author(s)
      Eskilsson A., Tachikawa M., Hosoya K., Blomqvist A.
    • Journal Title

      J. Comp. Neurol.

      Volume: (印刷中) Issue: 14 Pages: 3229-3244

    • DOI

      10.1002/cne.23593

    • Year and Date
      2014-04-08
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A clearance system for prostaglandin D2, a sleep-promoting factor, in the cerebrospinal fluid: role of the blood-cerebrospinal barrier transporters.2012

    • Author(s)
      Tachikawa M
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 343 Issue: 3 Pages: 608-616

    • DOI

      10.1124/jpet.112.197012

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of the blood-cerebrospinal fluid barrier transporter as a cerebral clearance system for prostaglandin E2 produced in the brain.2012

    • Author(s)
      Tachikawa M
    • Journal Title

      J Neurochem

      Volume: 123 Issue: 5 Pages: 750-760

    • DOI

      10.1111/jnc.12018

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Remarks]

    • URL

      http://www.pha.u-toyama.ac.jp/phaphzai/index-j.html

    • Related Report
      2013 Final Research Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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